YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Fluorescent Probes for Reactive Nitrogen Species
Alternative Title检测活性氮物种的荧光探针
Jing Xiaotong1,2; Yu Fabiao1; Chen Lingxin1; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
2014-05-01
Source PublicationPROGRESS IN CHEMISTRY
ISSN1005-281X
Volume26Issue:5Pages:866-878
Contribution Rank[Jing Xiaotong; Yu Fabiao; Chen Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Jing Xiaotong] Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Peoples R China
AbstractIt is generally established that the intracellular reactive nitrogen species (RNS) which contain nitrogen atoms are one class of highly chemical active species. These species have attracted increasing attention and become an active research field based on their key roles in special functions during a series of physiological and pathological processes. In order to elucidate these roles of RNS, the design and development technology for selective and sensitive detection to RNS in vivo are crucial. Advanced with high sensitivity, good selectivity, noninvasive detection and real-time visualization in situ, fluorescent probes provide facilitative and effective chemical approaches in modern biochemistry analysis. Progress in the field of fluorescent probes for RNS promises to advance our knowledge of essential cellular signal transduction during the varieties of physiological and pathological processes, which is indicated in human health and disease. According to the current situation, we review the past four years' latest five types of RNS probes for nitric oxide (NO), peroxynitrite (ONOO-), nitroxyl (HNO), nitrite (NO2-) and nitrogen dioxide (NO2). In this article, the design strategies, fluorescent response mechanisms and biological applications of the probes are discussed. Finally, the prospect to design and applications of probes is given.; It is generally established that the intracellular reactive nitrogen species (RNS) which contain nitrogen atoms are one class of highly chemical active species. These species have attracted increasing attention and become an active research field based on their key roles in special functions during a series of physiological and pathological processes. In order to elucidate these roles of RNS, the design and development technology for selective and sensitive detection to RNS in vivo are crucial. Advanced with high sensitivity, good selectivity, noninvasive detection and real-time visualization in situ, fluorescent probes provide facilitative and effective chemical approaches in modern biochemistry analysis. Progress in the field of fluorescent probes for RNS promises to advance our knowledge of essential cellular signal transduction during the varieties of physiological and pathological processes, which is indicated in human health and disease. According to the current situation, we review the past four years' latest five types of RNS probes for nitric oxide (NO), peroxynitrite (ONOO-), nitroxyl (HNO), nitrite (NO2-) and nitrogen dioxide (NO2). In this article, the design strategies, fluorescent response mechanisms and biological applications of the probes are discussed. Finally, the prospect to design and applications of probes is given.
KeywordReactive Nitrogen Species Fluorescent Probe Bioimaging Nitric Oxide Peroxynitrite
Department中科院海岸带环境过程与生态修复重点实验室
Subject AreaChemistry, Multidisciplinary
DOI10.7536/PC131025
Funding OrganizationChemistry
Indexed BySCI
WOS KeywordNITRIC-OXIDE PRODUCTION ; LIVING CELLS ; MACROPHAGE CELLS ; AQUEOUS-SOLUTION ; NITROXYL HNO ; PEROXYNITRITE DETECTION ; SELECTIVE DETECTION ; BIOLOGICAL-ACTIVITY ; LUMINESCENT PROBES ; IMAGING AGENT
SubtypeReview
Language英语
WOS Research AreaChemistry
WOS IDWOS:000336560200015
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/8750
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorChen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jing Xiaotong,Yu Fabiao,Chen Lingxin,et al. Fluorescent Probes for Reactive Nitrogen Species[J]. PROGRESS IN CHEMISTRY,2014,26(5):866-878.
APA Jing Xiaotong,Yu Fabiao,Chen Lingxin,&Chen, LX .(2014).Fluorescent Probes for Reactive Nitrogen Species.PROGRESS IN CHEMISTRY,26(5),866-878.
MLA Jing Xiaotong,et al."Fluorescent Probes for Reactive Nitrogen Species".PROGRESS IN CHEMISTRY 26.5(2014):866-878.
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