Fluorescent Probes for Reactive Nitrogen Species
其他题名检测活性氮物种的荧光探针
Jing Xiaotong1,2; Yu Fabiao1; Chen Lingxin1; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
发表期刊PROGRESS IN CHEMISTRY
ISSN1005-281X
2014-05-01
卷号26期号:5页码:866-878
关键词Reactive Nitrogen Species Fluorescent Probe Bioimaging Nitric Oxide Peroxynitrite
DOI10.7536/PC131025
产权排序[Jing Xiaotong; Yu Fabiao; Chen Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Jing Xiaotong] Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Peoples R China
作者部门中科院海岸带环境过程与生态修复重点实验室
英文摘要It is generally established that the intracellular reactive nitrogen species (RNS) which contain nitrogen atoms are one class of highly chemical active species. These species have attracted increasing attention and become an active research field based on their key roles in special functions during a series of physiological and pathological processes. In order to elucidate these roles of RNS, the design and development technology for selective and sensitive detection to RNS in vivo are crucial. Advanced with high sensitivity, good selectivity, noninvasive detection and real-time visualization in situ, fluorescent probes provide facilitative and effective chemical approaches in modern biochemistry analysis. Progress in the field of fluorescent probes for RNS promises to advance our knowledge of essential cellular signal transduction during the varieties of physiological and pathological processes, which is indicated in human health and disease. According to the current situation, we review the past four years' latest five types of RNS probes for nitric oxide (NO), peroxynitrite (ONOO-), nitroxyl (HNO), nitrite (NO2-) and nitrogen dioxide (NO2). In this article, the design strategies, fluorescent response mechanisms and biological applications of the probes are discussed. Finally, the prospect to design and applications of probes is given.; It is generally established that the intracellular reactive nitrogen species (RNS) which contain nitrogen atoms are one class of highly chemical active species. These species have attracted increasing attention and become an active research field based on their key roles in special functions during a series of physiological and pathological processes. In order to elucidate these roles of RNS, the design and development technology for selective and sensitive detection to RNS in vivo are crucial. Advanced with high sensitivity, good selectivity, noninvasive detection and real-time visualization in situ, fluorescent probes provide facilitative and effective chemical approaches in modern biochemistry analysis. Progress in the field of fluorescent probes for RNS promises to advance our knowledge of essential cellular signal transduction during the varieties of physiological and pathological processes, which is indicated in human health and disease. According to the current situation, we review the past four years' latest five types of RNS probes for nitric oxide (NO), peroxynitrite (ONOO-), nitroxyl (HNO), nitrite (NO2-) and nitrogen dioxide (NO2). In this article, the design strategies, fluorescent response mechanisms and biological applications of the probes are discussed. Finally, the prospect to design and applications of probes is given.
文章类型Review
资助机构Chemistry
收录类别SCI
语种英语
关键词[WOS]NITRIC-OXIDE PRODUCTION ; LIVING CELLS ; MACROPHAGE CELLS ; AQUEOUS-SOLUTION ; NITROXYL HNO ; PEROXYNITRITE DETECTION ; SELECTIVE DETECTION ; BIOLOGICAL-ACTIVITY ; LUMINESCENT PROBES ; IMAGING AGENT
研究领域[WOS]Chemistry
WOS记录号WOS:000336560200015
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/8750
专题中国科学院海岸带环境过程与生态修复重点实验室
通讯作者Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Peoples R China
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Jing Xiaotong,Yu Fabiao,Chen Lingxin,et al. Fluorescent Probes for Reactive Nitrogen Species[J]. PROGRESS IN CHEMISTRY,2014,26(5):866-878.
APA Jing Xiaotong,Yu Fabiao,Chen Lingxin,&Chen, LX .(2014).Fluorescent Probes for Reactive Nitrogen Species.PROGRESS IN CHEMISTRY,26(5),866-878.
MLA Jing Xiaotong,et al."Fluorescent Probes for Reactive Nitrogen Species".PROGRESS IN CHEMISTRY 26.5(2014):866-878.
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