Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether
Ji, Chenglong1,2; Zhao, Jianmin1; Wu, Huifeng1; Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
发表期刊ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
ISSN1382-6689
2014-05-01
卷号37期号:3页码:1116-1122
关键词Bde 47 Mytilus Galloprovincialis Toxicological Effects Nmr Metabolomics
DOI10.1016/j.etap.2014.04.007
产权排序[Ji, Chenglong; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China; [Ji, Chenglong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
作者部门中科院海岸带环境过程与生态修复重点实验室
英文摘要Polybrominated diphenyl ethers (PBDEs) are widely used as a class of brominated flame-retardants. As a congener of PBDEs, 2,2',4,4'-tetrabromodiphenylether (BDE 47) is the most toxic congener to animals. In this study, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Mytilus galloprovincialis exposed to BDE 47 for 30 days. Results indicated the apparent gender-specific responses in M. galloprovincialis with BDE 47 exposures (1 and 10 mu g/L) at metabolite level. Basically, BDE 47 induced disruption in osmotic regulation and altered energy metabolism in mussels, via differential metabolic pathways. In addition, the hormesis phenomenon was observed in both male and female mussel samples exposed the two concentrations of BDE 47, indicated by the contrarily altered metabolites from two BDE 47 treatments (1 and 10 mu g/L), respectively. Overall, this study confirmed the gender-specific responses to BDE 47 exposures in mussels and suggested the gender differences should be considered in marine ecotoxicology. (C) 2014 Elsevier B.V. All rights reserved.; Polybrominated diphenyl ethers (PBDEs) are widely used as a class of brominated flame-retardants. As a congener of PBDEs, 2,2',4,4'-tetrabromodiphenylether (BDE 47) is the most toxic congener to animals. In this study, we applied metabolomics to characterize the gender-specific metabolic responses in mussel Mytilus galloprovincialis exposed to BDE 47 for 30 days. Results indicated the apparent gender-specific responses in M. galloprovincialis with BDE 47 exposures (1 and 10 mu g/L) at metabolite level. Basically, BDE 47 induced disruption in osmotic regulation and altered energy metabolism in mussels, via differential metabolic pathways. In addition, the hormesis phenomenon was observed in both male and female mussel samples exposed the two concentrations of BDE 47, indicated by the contrarily altered metabolites from two BDE 47 treatments (1 and 10 mu g/L), respectively. Overall, this study confirmed the gender-specific responses to BDE 47 exposures in mussels and suggested the gender differences should be considered in marine ecotoxicology. (C) 2014 Elsevier B.V. All rights reserved.
文章类型Article
资助机构Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
收录类别SCI
语种英语
关键词[WOS]POLYBROMINATED DIPHENYL ETHERS ; ENVIRONMENTALLY RELEVANT CONCENTRATIONS ; CLAM RUDITAPES-PHILIPPINARUM ; NMR-BASED METABOLOMICS ; EXPOSURE ; SAMPLES ; CELLS ; BDE-47 ; HEALTH ; GILLS
研究领域[WOS]Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology
WOS记录号WOS:000338598200024
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/8748
专题中国科学院海岸带环境过程与生态修复重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Wu, HF (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
作者单位1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, YICCAS, Yantai Inst Coastal Zone Res YIC,Key Lab Coastal, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Ji, Chenglong,Zhao, Jianmin,Wu, Huifeng,et al. Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2014,37(3):1116-1122.
APA Ji, Chenglong,Zhao, Jianmin,Wu, Huifeng,&Wu, HF .(2014).Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,37(3),1116-1122.
MLA Ji, Chenglong,et al."Gender-specific metabolic responses in gonad of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 37.3(2014):1116-1122.
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