Fluorescent probes for hydrogen sulfide detection and bioimaging
Yu, Fabiao1; Han, Xiaoyue1,2; Chen, Lingxin1; Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
2014-10-21
发表期刊CHEMICAL COMMUNICATIONS
ISSN1359-7345
卷号50期号:82页码:12234-12249
产权排序[Yu, Fabiao; Han, Xiaoyue; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Han, Xiaoyue] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
摘要In comparison with other biological detection technologies, fluorescence bioimaging technology has become a powerful supporting tool for intracellular detection, and can provide attractive facilities for investigating physiological and pathological processes of interest with high spatial and temporal resolution, less invasiveness, and a rapid response. Due to the versatile roles of hydrogen sulfide (H2S) in cellular signal transduction and intracellular redox status regulation, fluorescent probes for the detection of this third signalling gasotransmitter have rapidly increased in number in recent years. These probes can offer powerful means to investigate the physiological actions of H2S in its native environments without disturbing its endogenous distribution. In this feature article, we address the synthesis and design strategies for the development of fluorescent probes for H2S based on the reaction type between H2S and the probes. Moreover, we also highlight fluorescent probes for other reactive sulfur species, such as sulfane sulfurs and SO2 derivatives.; In comparison with other biological detection technologies, fluorescence bioimaging technology has become a powerful supporting tool for intracellular detection, and can provide attractive facilities for investigating physiological and pathological processes of interest with high spatial and temporal resolution, less invasiveness, and a rapid response. Due to the versatile roles of hydrogen sulfide (H2S) in cellular signal transduction and intracellular redox status regulation, fluorescent probes for the detection of this third signalling gasotransmitter have rapidly increased in number in recent years. These probes can offer powerful means to investigate the physiological actions of H2S in its native environments without disturbing its endogenous distribution. In this feature article, we address the synthesis and design strategies for the development of fluorescent probes for H2S based on the reaction type between H2S and the probes. Moreover, we also highlight fluorescent probes for other reactive sulfur species, such as sulfane sulfurs and SO2 derivatives.
关键词Turn-on Probe Living Cells Selective Detection Hypobromous Acid Oxidative Stress High-sensitivity Aqueous-solution So2 Derivatives H2s Production Redox Cycle
作者部门中科院海岸带环境过程与生态修复重点实验室
学科领域Chemistry, Multidisciplinary
DOI10.1039/c4cc03312d
项目资助者Chemistry
收录类别SCI
关键词[WOS]TURN-ON PROBE ; LIVING CELLS ; SELECTIVE DETECTION ; HYPOBROMOUS ACID ; OXIDATIVE STRESS ; HIGH-SENSITIVITY ; AQUEOUS-SOLUTION ; SO2 DERIVATIVES ; H2S PRODUCTION ; REDOX CYCLE
文章类型Article
语种英语
WOS研究方向Chemistry
WOS记录号WOS:000342887100002
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/8700
专题中科院海岸带环境过程与生态修复重点实验室
通讯作者Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol Shandong, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
第一作者单位中国科学院烟台海岸带研究所
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GB/T 7714
Yu, Fabiao,Han, Xiaoyue,Chen, Lingxin,et al. Fluorescent probes for hydrogen sulfide detection and bioimaging[J]. CHEMICAL COMMUNICATIONS,2014,50(82):12234-12249.
APA Yu, Fabiao,Han, Xiaoyue,Chen, Lingxin,&Chen, LX .(2014).Fluorescent probes for hydrogen sulfide detection and bioimaging.CHEMICAL COMMUNICATIONS,50(82),12234-12249.
MLA Yu, Fabiao,et al."Fluorescent probes for hydrogen sulfide detection and bioimaging".CHEMICAL COMMUNICATIONS 50.82(2014):12234-12249.
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