YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo
Gao, Min1; Wang, Rui2; Yu, Fabiao2; You, Jinmao1; Chen, Lingxin1,2; Yu, FB (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. fbyu@yic.ac.cn; lxchen@yic.ac.cn
2015
Source PublicationANALYST
ISSN0003-2654
Volume140Issue:11Pages:3766-3772
Contribution Rank[Gao, Min; You, Jinmao; Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China; [Wang, Rui; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
AbstractHydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo.; Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo.
KeywordReactive Oxygen Sulfane Sulfur Sulfide H2s Cysteine Biology Persulfides Chemistry Design Thiols
Department中科院海岸带环境过程与生态修复重点实验室
Subject AreaChemistry, Analytical
DOI10.1039/c4an02366h
Funding OrganizationChemistry
Indexed BySCI
WOS KeywordREACTIVE OXYGEN ; SULFANE SULFUR ; SULFIDE ; H2S ; CYSTEINE ; BIOLOGY ; PERSULFIDES ; CHEMISTRY ; DESIGN ; THIOLS
SubtypeArticle
Language英语
WOS Research AreaChemistry
WOS IDWOS:000354650300011
Citation statistics
Cited Times:51[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/8615
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorYu, FB (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. fbyu@yic.ac.cn; lxchen@yic.ac.cn
Affiliation1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Gao, Min,Wang, Rui,Yu, Fabiao,et al. A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo[J]. ANALYST,2015,140(11):3766-3772.
APA Gao, Min.,Wang, Rui.,Yu, Fabiao.,You, Jinmao.,Chen, Lingxin.,...&lxchen@yic.ac.cn.(2015).A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo.ANALYST,140(11),3766-3772.
MLA Gao, Min,et al."A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo".ANALYST 140.11(2015):3766-3772.
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