A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo
Gao, Min1; Wang, Rui2; Yu, Fabiao2; You, Jinmao1; Chen, Lingxin1,2; Yu, FB (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. fbyu@yic.ac.cn; lxchen@yic.ac.cn
发表期刊ANALYST
ISSN0003-2654
2015
卷号140期号:11页码:3766-3772
关键词Reactive Oxygen Sulfane Sulfur Sulfide H2s Cysteine Biology Persulfides Chemistry Design Thiols
DOI10.1039/c4an02366h
产权排序[Gao, Min; You, Jinmao; Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China; [Wang, Rui; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
作者部门中科院海岸带环境过程与生态修复重点实验室
英文摘要Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo.; Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have been considered to be involved in cytoprotective processes and redox signaling. The emerging evidences imply that the actual signaling molecule is H2Sn rather than H2S. In this work, we present a near-infrared fluorescent probe BD-ss for the selective detection of H2Sn biosynthetic pathways in living cells and in vivo. The probe is constructed by equipping a bis-electrophilic H2Sn capture group p-nitrofluorobenzoate to a near-infrared fluorophore azo-BODIPY. BD-ss can provide a remarkable turn-on fluorescence response for assessing endogenous H2Sn formation ways in serum, in living cells and in vivo.
文章类型Article
资助机构Chemistry
收录类别SCI
语种英语
关键词[WOS]REACTIVE OXYGEN ; SULFANE SULFUR ; SULFIDE ; H2S ; CYSTEINE ; BIOLOGY ; PERSULFIDES ; CHEMISTRY ; DESIGN ; THIOLS
研究领域[WOS]Chemistry
WOS记录号WOS:000354650300011
引用统计
被引频次:65[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/8615
专题中国科学院海岸带环境过程与生态修复重点实验室
通讯作者Yu, FB (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. fbyu@yic.ac.cn; lxchen@yic.ac.cn
作者单位1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
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GB/T 7714
Gao, Min,Wang, Rui,Yu, Fabiao,et al. A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo[J]. ANALYST,2015,140(11):3766-3772.
APA Gao, Min.,Wang, Rui.,Yu, Fabiao.,You, Jinmao.,Chen, Lingxin.,...&lxchen@yic.ac.cn.(2015).A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo.ANALYST,140(11),3766-3772.
MLA Gao, Min,et al."A near-infrared fluorescent probe for the detection of hydrogen polysulfides biosynthetic pathways in living cells and in vivo".ANALYST 140.11(2015):3766-3772.
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