| Novel vanadyl complexes of alginate saccharides: Synthesis, characterization, and biological activities | |
Liu, Shengyi1,2; Liu, Guangyang1,2; Yi, Yuetao1 ; Yi, YT (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. yiyuetao@gmail.com
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| 发表期刊 | CARBOHYDRATE POLYMERS
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| ISSN | 0144-8617 |
| 2015-05-05 | |
| 卷号 | 121页码:86-91 |
| 关键词 | Vanadyl Alginate Polysaccharides Vanadyl Alginate Oligosaccharides Antioxidant Activity Antiproliferative Activity Protein Tyrosine Phosphatase 1b Cytocompatibility |
| DOI | 10.1016/j.carbpol.2014.11.069 |
| 产权排序 | [Liu, Shengyi; Liu, Guangyang; Yi, Yuetao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Liu, Shengyi; Liu, Guangyang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 作者部门 | 海岸带生物学与生物资源利用所重点实验室 |
| 英文摘要 | Vanadium compounds present many physiological functions. However, vanadium(IV) and (V) salts are difficult for gastrointestinal absorption and have strong side effects. Therefore organic oxovanadium compounds gain more attention. Vanadyl alginate polysaccharides (VAPS) and vanadyl alginate oligosaccharides (VAOS) were obtained from aqueous solutions of VOSO4 at pH 12. They were characterized by infrared spectroscopy, UV-vis spectroscopy and inductively coupled plasma-mass spectrometry (ICP-MS). The antioxidant activity of oxovanadium(IV) complexes was investigated in hydroxyl and DPPH radical scavenging systems in vitro. The results reveal that activities of VAPS and VAOS in the two systems were stronger than those of alginate polysaccharides (APS) and alginate oligosaccharides (AOS), respectively. In addition, VAPS and VAOS promoted significantly the antiproliferation of ligands of human hepatoma cell line BEL-7402. Oxovanadium(IV) complexes were potent inhibitors of protein tyrosine phosphatase 1B (PTP1B) with IC50 values in the range of 6.4-18.7 mu g/mL, indicated in biochemical assays. In addition, Vanadyl-alginate had no significant side effects on proliferation and viability of HL-7702 hepatic cells. In the future, they can be added to medicines and ease the growing threat that cancer and diabetes mellitus cause to human health. (C) 2014 Elsevier Ltd. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | Public Science and Technology Research Funds Projects of Ocean China 2011418027 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | RADICAL-SCAVENGING ACTIVITY ; ANTIOXIDATIVE ACTIVITIES ; CYTOKINE PRODUCTION ; HYDROGEN-PEROXIDE ; SCHIFF-BASES ; OLIGOSACCHARIDES ; CHITOSAN ; INHIBITION ; DEPOLYMERIZATION ; POLYSACCHARIDES |
| 研究领域[WOS] | Chemistry ; Chemistry; Polymer Science |
| WOS记录号 | WOS:000350182400011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/8503 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Yi, YT (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. yiyuetao@gmail.com |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Shengyi,Liu, Guangyang,Yi, Yuetao,et al. Novel vanadyl complexes of alginate saccharides: Synthesis, characterization, and biological activities[J]. CARBOHYDRATE POLYMERS,2015,121:86-91. |
| APA | Liu, Shengyi,Liu, Guangyang,Yi, Yuetao,&Yi, YT .(2015).Novel vanadyl complexes of alginate saccharides: Synthesis, characterization, and biological activities.CARBOHYDRATE POLYMERS,121,86-91. |
| MLA | Liu, Shengyi,et al."Novel vanadyl complexes of alginate saccharides: Synthesis, characterization, and biological activities".CARBOHYDRATE POLYMERS 121(2015):86-91. |
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