Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47) | |
| 其他题名 | Synthesis and Electroluminescence of Thieno-[3,4-b]pyrazine-cored Molecule with Fluorinated Shell.pdf |
Ji, Chenglong1,2 ; Wu, Huifeng1; Wei, Lei1,2; Zhao, Jianmin1; Yu, Junbao1
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| 发表期刊 | AQUATIC TOXICOLOGY
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| ISSN | 0166-445X |
| 2013-09-15 | |
| 卷号 | 140页码:449-457 |
| 关键词 | Bde 47 Mytilus Galloprovincialis Toxicological Effects Proteomics Metabolomics |
| 产权排序 | [Ji, Chenglong; Wu, Huifeng; Wei, Lei; Zhao, Jianmin; Yu, Junbao] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China; [Ji, Chenglong; Wei, Lei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China. hfwu@yic.ac.cn |
| 英文摘要 | Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame-retardants (BFRs) that are widely used in industrial products and have posed potential risk on the coastal environment of the Laizhou Bay in China. They are of great concern due to their toxicities, such as hepatotoxicity, carcinogenecity, neurotoxicity, immunotoxicity and endocrine disrupting effects in animals. In this work, we focused on the gender-specific responses of BDE 47 in mussel Mytilus galloprovincialis using a combined proteomic and metabolomic approach. Metabolic responses indicated that BDE 47 mainly caused disturbance in energy metabolism in male mussel gills. For female mussel samples, disruption in both osmotic regulation and energy metabolism was found in terms of differential metabolic profiles. Proteomic responses revealed that BDE 47 induced cell apoptosis and reduced reactive oxygen species (ROS) production in both male and female mussels, disturbance in protein homeostasis in male mussels as well as disturbance in female mussel proteolysis based on the differential proteomic biomarkers. Overall, these results confirmed the gender-specific responses in mussels to ODE 47 exposures. This work demonstrated that an integrated metabolomic and proteomic approach could provide an important insight into the toxicological effects of environmental pollutant to organisms. (C) 2013 Elsevier B.V. All rights reserved.; Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame-retardants (BFRs) that are widely used in industrial products and have posed potential risk on the coastal environment of the Laizhou Bay in China. They are of great concern due to their toxicities, such as hepatotoxicity, carcinogenecity, neurotoxicity, immunotoxicity and endocrine disrupting effects in animals. In this work, we focused on the gender-specific responses of BDE 47 in mussel Mytilus galloprovincialis using a combined proteomic and metabolomic approach. Metabolic responses indicated that BDE 47 mainly caused disturbance in energy metabolism in male mussel gills. For female mussel samples, disruption in both osmotic regulation and energy metabolism was found in terms of differential metabolic profiles. Proteomic responses revealed that BDE 47 induced cell apoptosis and reduced reactive oxygen species (ROS) production in both male and female mussels, disturbance in protein homeostasis in male mussels as well as disturbance in female mussel proteolysis based on the differential proteomic biomarkers. Overall, these results confirmed the gender-specific responses in mussels to ODE 47 exposures. This work demonstrated that an integrated metabolomic and proteomic approach could provide an important insight into the toxicological effects of environmental pollutant to organisms. (C) 2013 Elsevier B.V. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | Chinese Academy of Sciences [KZZD-EW-14-03] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | POLYBROMINATED DIPHENYL ETHERS ; LASER-DESORPTION/IONIZATION-TIME ; EARTHWORM EISENIA-FOETIDA ; FLAME RETARDANTS ; EXPOSURE ; PROTEIN ; CELLS ; EXPRESSION ; CHINA ; PBDES |
| 研究领域[WOS] | Marine & Freshwater Biology ; Toxicology |
| WOS记录号 | WOS:000324900800049 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/6951 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_滨海湿地实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Chenglong,Wu, Huifeng,Wei, Lei,et al. Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47)[J]. AQUATIC TOXICOLOGY,2013,140:449-457. |
| APA | Ji, Chenglong,Wu, Huifeng,Wei, Lei,Zhao, Jianmin,&Yu, Junbao.(2013).Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47).AQUATIC TOXICOLOGY,140,449-457. |
| MLA | Ji, Chenglong,et al."Proteomic and metabolomic analysis reveal gender-specific responses of mussel Mytilus galloprovincialis to 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE 47)".AQUATIC TOXICOLOGY 140(2013):449-457. |
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