Reporter-Free Potentiometric Sensing of Boronic Acids and Their Reactions by Using Quaternary Ammonium Salt-Functionalized Polymeric Liquid Membranes
其他题名Toxicity of single-walled carbon nanotubes on green microalga Chromochloris zofingiensis.pdf
Wang, Xuewei1,2,3; Yue, Dengfeng4; Lv, Enguang1,2; Wu, Lei1,2; Qin, Wei1,2
2014-02-18
发表期刊ANALYTICAL CHEMISTRY
ISSN0003-2700
卷号86期号:4页码:1927-1931
产权排序[Wang, Xuewei; Lv, Enguang; Wu, Lei; Qin, Wei] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China; [Wang, Xuewei; Lv, Enguang; Wu, Lei; Qin, Wei] YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China; [Wang, Xuewei] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Yue, Dengfeng] Yantai Univ, Coll Chem & Chem Engn, Yantai 264003, Shandong, Peoples R China
摘要The tremendous applications of boronic acids (BAs) in chemical sensing, medical chemistry, molecular assembly, and organic synthesis lead to an urgent demand for developing effective sensing methods for BAs. This paper reports a facile and sensitive potentiometric sensor scheme for heterogeneous detection of BAs based on their unexpected potential responses on quaternary ammonium salt-doped polymeric liquid membranes. B-11 NMR data reveal that a quaternary ammonium chloride can trigger the hydrolysis of an electrically neutral BA in an aprotic solvent. Using the quaternary ammonium salt as the receptor, the BA molecules can be extracted from the sample solution into the polymeric membrane phase and undergo the concomitant hydrolysis. Such salt-triggered hydrolysis generates H+ ions, which can be coejected into the aqueous phase with the counterions (e.g., Cl-) owing to their high hydrophilicities. The perturbation on the ionic partition at the sample-membrane interface changes the phase boundary potential and thus enables the potentiometric sensing of BAs. In contrast to other transduction methods for BAs, for which labeled or separate reporters are exclusively required, the present heterogeneous sensing scheme allows the direct detection of BAs without using any reporter molecules. This technique shows superior detection limits for BAs (e.g., 1.0 x 10(-6) M for phenylboronic acid) as compared to previously reported methods based on colorimetry, fluorimetry, and mass spectrometry. The proposed sensing strategy has also been successfully applied to potentiometric indication of the BA reactions with hydrogen peroxide and saccharides, which allows indirect and sensitive detection of these important species.; The tremendous applications of boronic acids (BAs) in chemical sensing, medical chemistry, molecular assembly, and organic synthesis lead to an urgent demand for developing effective sensing methods for BAs. This paper reports a facile and sensitive potentiometric sensor scheme for heterogeneous detection of BAs based on their unexpected potential responses on quaternary ammonium salt-doped polymeric liquid membranes. B-11 NMR data reveal that a quaternary ammonium chloride can trigger the hydrolysis of an electrically neutral BA in an aprotic solvent. Using the quaternary ammonium salt as the receptor, the BA molecules can be extracted from the sample solution into the polymeric membrane phase and undergo the concomitant hydrolysis. Such salt-triggered hydrolysis generates H+ ions, which can be coejected into the aqueous phase with the counterions (e.g., Cl-) owing to their high hydrophilicities. The perturbation on the ionic partition at the sample-membrane interface changes the phase boundary potential and thus enables the potentiometric sensing of BAs. In contrast to other transduction methods for BAs, for which labeled or separate reporters are exclusively required, the present heterogeneous sensing scheme allows the direct detection of BAs without using any reporter molecules. This technique shows superior detection limits for BAs (e.g., 1.0 x 10(-6) M for phenylboronic acid) as compared to previously reported methods based on colorimetry, fluorimetry, and mass spectrometry. The proposed sensing strategy has also been successfully applied to potentiometric indication of the BA reactions with hydrogen peroxide and saccharides, which allows indirect and sensitive detection of these important species.
通讯作者Qin, W (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China. wqin@yic.ac.cn
关键词Phenylboronic Acid Affinity-chromatography Ion Recognition Electrodes Diol Esterification Complexation Saccharides Derivatives
学科领域Chemistry, Analytical
项目资助者Instrument Developing Project of the Chinese Academy of Sciences [YZ201161]; National Natural Science Foundation of China [41176081]; Taishan Scholar Program of Shandong Province [TS20081159]
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收录类别SCI
关键词[WOS]PHENYLBORONIC ACID ; AFFINITY-CHROMATOGRAPHY ; ION ; RECOGNITION ; ELECTRODES ; DIOL ; ESTERIFICATION ; COMPLEXATION ; SACCHARIDES ; DERIVATIVES
文章类型Article
语种英语
资助项目中国科学院海岸带环境过程与生态修复重点实验室
WOS研究方向Chemistry
WOS记录号WOS:000331775600001
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被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/6903
专题中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China
2.YICCAS, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
4.Yantai Univ, Coll Chem & Chem Engn, Yantai 264003, Shandong, Peoples R China
第一作者单位中国科学院烟台海岸带研究所
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Wang, Xuewei,Yue, Dengfeng,Lv, Enguang,et al. Reporter-Free Potentiometric Sensing of Boronic Acids and Their Reactions by Using Quaternary Ammonium Salt-Functionalized Polymeric Liquid Membranes[J]. ANALYTICAL CHEMISTRY,2014,86(4):1927-1931.
APA Wang, Xuewei,Yue, Dengfeng,Lv, Enguang,Wu, Lei,&Qin, Wei.(2014).Reporter-Free Potentiometric Sensing of Boronic Acids and Their Reactions by Using Quaternary Ammonium Salt-Functionalized Polymeric Liquid Membranes.ANALYTICAL CHEMISTRY,86(4),1927-1931.
MLA Wang, Xuewei,et al."Reporter-Free Potentiometric Sensing of Boronic Acids and Their Reactions by Using Quaternary Ammonium Salt-Functionalized Polymeric Liquid Membranes".ANALYTICAL CHEMISTRY 86.4(2014):1927-1931.
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