SERS Tags: Novel Optical Nanoprobes for Bioanalysis

	SERS Tags: Novel Optical Nanoprobes for Bioanalysis
	Wang, Yunqing1 ; Yan, Bing 2; Chen, Lingxin1
	2013-03-01
发表期刊	CHEMICAL REVIEWS
卷号	113 期号:3 页码:1391-1428
产权排序	[Wang, Yunqing; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Yan, Bing] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
摘要	CONTENTS 1. Introduction 1.1. Fundamental Theory of Surface-Enhanced Raman Scattering 1.2. Optical Properties of SERS Tags 2. Synthesis of SERS Tags 2.1. Noble Metal Nanosubstrates 2.1.1. Single Particle-Based SERS Substrates 2.1.2. Nanoparticle Cluster-Based Substrates 2.2. Raman Reporter Molecules 2.2.1. Selection Principles and Reporter Types 2.2.2. Self-Assembled Monolayer Coverage Strategy 2.3. Surface Coating for Protection 2.3.1. Biomolecule Coating 2.3.2. Polymer Coating 2.3.3. Liposome Coating 2.3.4. Silica Coating 2.4. Attachment of Targeting Molecules 3. Bioanalysis Applications 3.1. Ionic and Molecular Detection 3.2. Pathogen Detection 3.3. Live-Cell Imaging 3.3.1. Cancer Marker Detection 3.3.2. Intercellular Microenvironment Sensing 3.4. Tissue SERS Imaging 3.5. In Vivo SERS Imaging 4. Challenges and Perspectives 4.1. Reproducible Signal of SERS Tags 4.1.1. Precisely Controlled Hot Spots for Nanosubstrates 4.1.2. Calibration of SERS Intensities and Enhancements 4.2. Improving Multiplexing Capability 4.3. Reduced Size for Subcellular Imaging 4.4. Development of Multifunctional Nanoplatforms 4.4.1. Magnetic SERS Dots 4.4.2. Multimodal Imaging Dots 4.4.3. SERS Tag-Based Therapeutic Systems 4.5. Biocompatibility 5. Conclusions and Remarks
通讯作者	Chen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
关键词	Surface-enhanced-raman Vivo Cancer-detection Functionalized Silver Nanoparticles Organic-inorganic Nanoparticles Stabilized Gold Nanoparticles Size-exclusion Chromatography Nanoaggregate-embedded Beads Single-molecule Detection Core-shell Nanoparticles In-vivo
学科领域	Hemistry ; Multidisciplinary
项目资助者	National Natural Science Foundation of China [21275158, 20975089, 81102415, 21077068, 21137002]; National Basic Research Program of China (973 Program) [2010CB933504]; Innovation Projects of the Chinese Academy of Sciences [KZCX2-EW-206]; One Hundred Person Project of the Chinese Academy of Sciences; Natural Science Foundation of Shandong Province of China [ZR2010BQ012]
收录类别	SCI
关键词[WOS]	SURFACE-ENHANCED-RAMAN ; VIVO CANCER-DETECTION ; FUNCTIONALIZED SILVER NANOPARTICLES ; ORGANIC-INORGANIC NANOPARTICLES ; STABILIZED GOLD NANOPARTICLES ; SIZE-EXCLUSION CHROMATOGRAPHY ; NANOAGGREGATE-EMBEDDED BEADS ; SINGLE-MOLECULE DETECTION ; CORE-SHELL NANOPARTICLES ; IN-VIVO
文章类型	Review
语种	英语
WOS研究方向	Chemistry
WOS记录号	WOS:000316243600003
引用统计	被引频次：519[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/6371
专题	中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 2.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
第一作者单位	中国科学院烟台海岸带研究所
推荐引用方式 GB/T 7714	Wang, Yunqing,Yan, Bing,Chen, Lingxin. SERS Tags: Novel Optical Nanoprobes for Bioanalysis[J]. CHEMICAL REVIEWS,2013,113(3):1391-1428.
APA	Wang, Yunqing,Yan, Bing,&Chen, Lingxin.(2013).SERS Tags: Novel Optical Nanoprobes for Bioanalysis.CHEMICAL REVIEWS,113(3),1391-1428.
MLA	Wang, Yunqing,et al."SERS Tags: Novel Optical Nanoprobes for Bioanalysis".CHEMICAL REVIEWS 113.3(2013):1391-1428.

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