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SERS Tags: Novel Optical Nanoprobes for Bioanalysis
Wang, Yunqing1; Yan, Bing2; Chen, Lingxin1
Source PublicationCHEMICAL REVIEWS
2013-03-01
Volume113Issue:3Pages:1391-1428
KeywordSurface-enhanced-raman Vivo Cancer-detection Functionalized Silver Nanoparticles Organic-inorganic Nanoparticles Stabilized Gold Nanoparticles Size-exclusion Chromatography Nanoaggregate-embedded Beads Single-molecule Detection Core-shell Nanoparticles In-vivo
Contribution Rank[Wang, Yunqing; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Yan, Bing] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
Corresponding AuthorChen, LX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
Abstract
  • CONTENTS
  • 1. Introduction
    • 1.1. Fundamental Theory of Surface-Enhanced Raman Scattering
    • 1.2. Optical Properties of SERS Tags
  • 2. Synthesis of SERS Tags
    • 2.1. Noble Metal Nanosubstrates
      • 2.1.1. Single Particle-Based SERS Substrates
      • 2.1.2. Nanoparticle Cluster-Based Substrates
    • 2.2. Raman Reporter Molecules
      • 2.2.1. Selection Principles and Reporter Types
      • 2.2.2. Self-Assembled Monolayer Coverage Strategy
    • 2.3. Surface Coating for Protection
      • 2.3.1. Biomolecule Coating
      • 2.3.2. Polymer Coating
      • 2.3.3. Liposome Coating
      • 2.3.4. Silica Coating
    • 2.4. Attachment of Targeting Molecules
  • 3. Bioanalysis Applications
    • 3.1. Ionic and Molecular Detection
    • 3.2. Pathogen Detection
    • 3.3. Live-Cell Imaging
      • 3.3.1. Cancer Marker Detection
      • 3.3.2. Intercellular Microenvironment Sensing
    • 3.4. Tissue SERS Imaging
    • 3.5. In Vivo SERS Imaging
  • 4. Challenges and Perspectives
    • 4.1. Reproducible Signal of SERS Tags
      • 4.1.1. Precisely Controlled Hot Spots for Nanosubstrates
      • 4.1.2. Calibration of SERS Intensities and Enhancements
    • 4.2. Improving Multiplexing Capability
    • 4.3. Reduced Size for Subcellular Imaging
    • 4.4. Development of Multifunctional Nanoplatforms
      • 4.4.1. Magnetic SERS Dots
      • 4.4.2. Multimodal Imaging Dots
      • 4.4.3. SERS Tag-Based Therapeutic Systems
    • 4.5. Biocompatibility
  • 5. Conclusions and Remarks
Funding OrganizationNational Natural Science Foundation of China [21275158, 20975089, 81102415, 21077068, 21137002]; National Basic Research Program of China (973 Program) [2010CB933504]; Innovation Projects of the Chinese Academy of Sciences [KZCX2-EW-206]; One Hundred Person Project of the Chinese Academy of Sciences; Natural Science Foundation of Shandong Province of China [ZR2010BQ012]
SubtypeReview
Indexed BySCI
Language英语
WOS KeywordSURFACE-ENHANCED-RAMAN ; VIVO CANCER-DETECTION ; FUNCTIONALIZED SILVER NANOPARTICLES ; ORGANIC-INORGANIC NANOPARTICLES ; STABILIZED GOLD NANOPARTICLES ; SIZE-EXCLUSION CHROMATOGRAPHY ; NANOAGGREGATE-EMBEDDED BEADS ; SINGLE-MOLECULE DETECTION ; CORE-SHELL NANOPARTICLES ; IN-VIVO
WOS Research AreaChemistry
WOS IDWOS:000316243600003
Citation statistics
Cited Times:817[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/6371
Collection中科院海岸带环境过程与生态修复重点实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
2.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
Recommended Citation
GB/T 7714		 Wang, Yunqing,Yan, Bing,Chen, Lingxin. SERS Tags: Novel Optical Nanoprobes for Bioanalysis[J]. CHEMICAL REVIEWS,2013,113(3):1391-1428.
APA Wang, Yunqing,Yan, Bing,&Chen, Lingxin.(2013).SERS Tags: Novel Optical Nanoprobes for Bioanalysis.CHEMICAL REVIEWS,113(3),1391-1428.
MLA Wang, Yunqing,et al."SERS Tags: Novel Optical Nanoprobes for Bioanalysis".CHEMICAL REVIEWS 113.3(2013):1391-1428.
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