YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures
Liao, Chunyang1,2,3; Liu, Fang1,2; Alomirah, Husam4; Vu Duc Loi5; Mohd, Mustafa Ali6; Moon, Hyo-Bang7; Nakata, Haruhiko8; Kannan, Kurunthachalam1,2,9
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
2012-06-19
Volume46Issue:12Pages:6860-6866
KeywordLiquid-chromatography Mass-spectrometry Us Population Hplc-ms/ms a Bpa Toxicity Receptor Analogs Paper
Contribution Rank[Liao, Chunyang; Liu, Fang; Kannan, Kurunthachalam] SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Albany, NY 12201 USA; [Liao, Chunyang; Liu, Fang; Kannan, Kurunthachalam] SUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Albany, NY 12201 USA; [Liao, Chunyang] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Shandong, Peoples R China; [Alomirah, Husam] Kuwait Inst Sci Res, Dept Biotechnol, Safat 13109, Kuwait; [Vu Duc Loi] Vietnam Acad Sci & Technol, Inst Chem, Hanoi, Vietnam; [Mohd, Mustafa Ali] Univ Malaya, Fac Med, Kuala Lumpur, Malaysia; [Moon, Hyo-Bang] Hanyang Univ, Coll Sci & Technol, Dept Environm Marine Sci, Ansan 426791, South Korea; [Nakata, Haruhiko] Kumamoto Univ, Grad Sch Sci & Technol, Kumamoto 8608555, Japan; [Kannan, Kurunthachalam] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Int Joint Res Ctr Persistent Tox Subst, Harbin 150090, Peoples R China
Corresponding AuthorKannan, K (reprint author), SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Empire State Plaza,POB 509, Albany, NY 12201 USA.,kkannan@wadsworth.org
Department中科院海岸带环境过程与生态修复重点实验室
AbstractAs concern regarding the toxic effects of bisphenol A (BPA) grows, BPA in many consumer products is gradually being replaced with compounds such as bisphenol S (BPS). Nevertheless, data on the occurrence of BPS in human specimens are limited. In this study, 315 urine samples, collected from the general populations in the United States, China, India, Japan, Korea, Kuwait, Malaysia, and Vietnam, were analyzed for the presence of total BPS (free plus conjugated) concentrations by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). BPS was detected in 81% of the urine samples analyzed at concentrations ranging from below the limit of quantitation (LOQ 0.02 ng/mL) to 21 ng/mL (geometric mean: 0.168 ng/mL). The urinary BPS concentration varied among countries, and the highest geometric mean concentration [1.18 ng/mL or 0.933 mu g/g creatinine (Cre)] of BPS was found in urine samples from Japan, followed by the United States (0.299 ng/mL, 0.304 mu g/g Cre), China (0.226 mu g/mL, 0.223 mu g/g Cre), Kuwait (0.172 ng/mL, 0.126 mu g/g Cre), and Vietnam (0.160 ng/mL, 0.148 mu g/g Cre). Median concentrations of BPS in urine samples from the Asian countries were 1 order of magnitude lower than the median concentrations reported earlier for BPA in the same set of samples, with the exception of samples from Japan. There were no significant differences in BPS concentrations between genders (male versus female), or among age groups (categorized as <= 19, 20-29, 30-39, 40-49, and >= 50 years), or races (Caucasian versus Asian). The daily intake (EDI) of BPS was estimated on the basis of urinary concentrations using a simple pharmacokinetic approach. The median EDI values of BPS in Japan, China, United States, Kuwait, Vietnam, Malaysia, India, and Korea were 1.67, 0.339, 0.316, 0.292, 0.217, 0.122, 0.084, and 0.023 mu g/person, respectively. This is the first study to report the occurrence of BPS in human urine.; As concern regarding the toxic effects of bisphenol A (BPA) grows, BPA in many consumer products is gradually being replaced with compounds such as bisphenol S (BPS). Nevertheless, data on the occurrence of BPS in human specimens are limited. In this study, 315 urine samples, collected from the general populations in the United States, China, India, Japan, Korea, Kuwait, Malaysia, and Vietnam, were analyzed for the presence of total BPS (free plus conjugated) concentrations by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). BPS was detected in 81% of the urine samples analyzed at concentrations ranging from below the limit of quantitation (LOQ 0.02 ng/mL) to 21 ng/mL (geometric mean: 0.168 ng/mL). The urinary BPS concentration varied among countries, and the highest geometric mean concentration [1.18 ng/mL or 0.933 mu g/g creatinine (Cre)] of BPS was found in urine samples from Japan, followed by the United States (0.299 ng/mL, 0.304 mu g/g Cre), China (0.226 mu g/mL, 0.223 mu g/g Cre), Kuwait (0.172 ng/mL, 0.126 mu g/g Cre), and Vietnam (0.160 ng/mL, 0.148 mu g/g Cre). Median concentrations of BPS in urine samples from the Asian countries were 1 order of magnitude lower than the median concentrations reported earlier for BPA in the same set of samples, with the exception of samples from Japan. There were no significant differences in BPS concentrations between genders (male versus female), or among age groups (categorized as <= 19, 20-29, 30-39, 40-49, and >= 50 years), or races (Caucasian versus Asian). The daily intake (EDI) of BPS was estimated on the basis of urinary concentrations using a simple pharmacokinetic approach. The median EDI values of BPS in Japan, China, United States, Kuwait, Vietnam, Malaysia, India, and Korea were 1.67, 0.339, 0.316, 0.292, 0.217, 0.122, 0.084, and 0.023 mu g/person, respectively. This is the first study to report the occurrence of BPS in human urine.
Funding OrganizationCenters for Disease Control and Prevention (CDC, Atlanta, GA)[1U38EH000464-01]; National Natural Science Foundation of China[20907039]; Department of Science and Technology of Shandong Province[BS2009HZ003]
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordLIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; US POPULATION ; HPLC-MS/MS ; A BPA ; TOXICITY ; RECEPTOR ; ANALOGS ; PAPER
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS IDWOS:000305320900054
Citation statistics
Cited Times:306[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/5966
Collection中科院海岸带环境过程与生态修复重点实验室
Affiliation1.SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Albany, NY 12201 USA
2.SUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Albany, NY 12201 USA
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Shandong, Peoples R China
4.Kuwait Inst Sci Res, Dept Biotechnol, Safat 13109, Kuwait
5.Vietnam Acad Sci & Technol, Inst Chem, Hanoi, Vietnam
6.Univ Malaya, Fac Med, Kuala Lumpur, Malaysia
7.Hanyang Univ, Coll Sci & Technol, Dept Environm Marine Sci, Ansan 426791, South Korea
8.Kumamoto Univ, Grad Sch Sci & Technol, Kumamoto 8608555, Japan
9.Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Int Joint Res Ctr Persistent Tox Subst, Harbin 150090, Peoples R China
Recommended Citation
GB/T 7714
Liao, Chunyang,Liu, Fang,Alomirah, Husam,et al. Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2012,46(12):6860-6866.
APA Liao, Chunyang.,Liu, Fang.,Alomirah, Husam.,Vu Duc Loi.,Mohd, Mustafa Ali.,...&Kannan, Kurunthachalam.(2012).Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures.ENVIRONMENTAL SCIENCE & TECHNOLOGY,46(12),6860-6866.
MLA Liao, Chunyang,et al."Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures".ENVIRONMENTAL SCIENCE & TECHNOLOGY 46.12(2012):6860-6866.
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