Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures
Liao, Chunyang1,2,3; Liu, Fang1,2; Alomirah, Husam4; Vu Duc Loi5; Mohd, Mustafa Ali6; Moon, Hyo-Bang7; Nakata, Haruhiko8; Kannan, Kurunthachalam1,2,9
2012-06-19
发表期刊ENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
卷号46期号:12页码:6860-6866
产权排序[Liao, Chunyang; Liu, Fang; Kannan, Kurunthachalam] SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Albany, NY 12201 USA; [Liao, Chunyang; Liu, Fang; Kannan, Kurunthachalam] SUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Albany, NY 12201 USA; [Liao, Chunyang] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Shandong, Peoples R China; [Alomirah, Husam] Kuwait Inst Sci Res, Dept Biotechnol, Safat 13109, Kuwait; [Vu Duc Loi] Vietnam Acad Sci & Technol, Inst Chem, Hanoi, Vietnam; [Mohd, Mustafa Ali] Univ Malaya, Fac Med, Kuala Lumpur, Malaysia; [Moon, Hyo-Bang] Hanyang Univ, Coll Sci & Technol, Dept Environm Marine Sci, Ansan 426791, South Korea; [Nakata, Haruhiko] Kumamoto Univ, Grad Sch Sci & Technol, Kumamoto 8608555, Japan; [Kannan, Kurunthachalam] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Int Joint Res Ctr Persistent Tox Subst, Harbin 150090, Peoples R China
摘要As concern regarding the toxic effects of bisphenol A (BPA) grows, BPA in many consumer products is gradually being replaced with compounds such as bisphenol S (BPS). Nevertheless, data on the occurrence of BPS in human specimens are limited. In this study, 315 urine samples, collected from the general populations in the United States, China, India, Japan, Korea, Kuwait, Malaysia, and Vietnam, were analyzed for the presence of total BPS (free plus conjugated) concentrations by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). BPS was detected in 81% of the urine samples analyzed at concentrations ranging from below the limit of quantitation (LOQ 0.02 ng/mL) to 21 ng/mL (geometric mean: 0.168 ng/mL). The urinary BPS concentration varied among countries, and the highest geometric mean concentration [1.18 ng/mL or 0.933 mu g/g creatinine (Cre)] of BPS was found in urine samples from Japan, followed by the United States (0.299 ng/mL, 0.304 mu g/g Cre), China (0.226 mu g/mL, 0.223 mu g/g Cre), Kuwait (0.172 ng/mL, 0.126 mu g/g Cre), and Vietnam (0.160 ng/mL, 0.148 mu g/g Cre). Median concentrations of BPS in urine samples from the Asian countries were 1 order of magnitude lower than the median concentrations reported earlier for BPA in the same set of samples, with the exception of samples from Japan. There were no significant differences in BPS concentrations between genders (male versus female), or among age groups (categorized as <= 19, 20-29, 30-39, 40-49, and >= 50 years), or races (Caucasian versus Asian). The daily intake (EDI) of BPS was estimated on the basis of urinary concentrations using a simple pharmacokinetic approach. The median EDI values of BPS in Japan, China, United States, Kuwait, Vietnam, Malaysia, India, and Korea were 1.67, 0.339, 0.316, 0.292, 0.217, 0.122, 0.084, and 0.023 mu g/person, respectively. This is the first study to report the occurrence of BPS in human urine.; As concern regarding the toxic effects of bisphenol A (BPA) grows, BPA in many consumer products is gradually being replaced with compounds such as bisphenol S (BPS). Nevertheless, data on the occurrence of BPS in human specimens are limited. In this study, 315 urine samples, collected from the general populations in the United States, China, India, Japan, Korea, Kuwait, Malaysia, and Vietnam, were analyzed for the presence of total BPS (free plus conjugated) concentrations by high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). BPS was detected in 81% of the urine samples analyzed at concentrations ranging from below the limit of quantitation (LOQ 0.02 ng/mL) to 21 ng/mL (geometric mean: 0.168 ng/mL). The urinary BPS concentration varied among countries, and the highest geometric mean concentration [1.18 ng/mL or 0.933 mu g/g creatinine (Cre)] of BPS was found in urine samples from Japan, followed by the United States (0.299 ng/mL, 0.304 mu g/g Cre), China (0.226 mu g/mL, 0.223 mu g/g Cre), Kuwait (0.172 ng/mL, 0.126 mu g/g Cre), and Vietnam (0.160 ng/mL, 0.148 mu g/g Cre). Median concentrations of BPS in urine samples from the Asian countries were 1 order of magnitude lower than the median concentrations reported earlier for BPA in the same set of samples, with the exception of samples from Japan. There were no significant differences in BPS concentrations between genders (male versus female), or among age groups (categorized as <= 19, 20-29, 30-39, 40-49, and >= 50 years), or races (Caucasian versus Asian). The daily intake (EDI) of BPS was estimated on the basis of urinary concentrations using a simple pharmacokinetic approach. The median EDI values of BPS in Japan, China, United States, Kuwait, Vietnam, Malaysia, India, and Korea were 1.67, 0.339, 0.316, 0.292, 0.217, 0.122, 0.084, and 0.023 mu g/person, respectively. This is the first study to report the occurrence of BPS in human urine.
通讯作者Kannan, K (reprint author), SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Empire State Plaza,POB 509, Albany, NY 12201 USA.,kkannan@wadsworth.org
关键词Liquid-chromatography Mass-spectrometry Us Population Hplc-ms/ms a Bpa Toxicity Receptor Analogs Paper
作者部门中科院海岸带环境过程与生态修复重点实验室
学科领域Engineering, Environmental ; Environmental Sciences
项目资助者Centers for Disease Control and Prevention (CDC, Atlanta, GA)[1U38EH000464-01]; National Natural Science Foundation of China[20907039]; Department of Science and Technology of Shandong Province[BS2009HZ003]
收录类别SCI
关键词[WOS]LIQUID-CHROMATOGRAPHY ; MASS-SPECTROMETRY ; US POPULATION ; HPLC-MS/MS ; A BPA ; TOXICITY ; RECEPTOR ; ANALOGS ; PAPER
文章类型Article
语种英语
资助项目Liao, Chunyang; Liu, Fang; Alomirah, Husam; Vu Duc Loi; Mohd, Mustafa Ali; Moon, Hyo-Bang; Nakata, Haruhiko; Kannan, Kurunthachalam
WOS研究方向Engineering ; Environmental Sciences & Ecology
WOS记录号WOS:000305320900054
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/5966
专题中科院海岸带环境过程与生态修复重点实验室
作者单位1.SUNY Albany, Wadsworth Ctr, New York State Dept Hlth, Albany, NY 12201 USA
2.SUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Albany, NY 12201 USA
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Zone Environm Proc, Key Lab Coastal Zone Environm Proc,YICCAS, Yantai 264003, Shandong, Peoples R China
4.Kuwait Inst Sci Res, Dept Biotechnol, Safat 13109, Kuwait
5.Vietnam Acad Sci & Technol, Inst Chem, Hanoi, Vietnam
6.Univ Malaya, Fac Med, Kuala Lumpur, Malaysia
7.Hanyang Univ, Coll Sci & Technol, Dept Environm Marine Sci, Ansan 426791, South Korea
8.Kumamoto Univ, Grad Sch Sci & Technol, Kumamoto 8608555, Japan
9.Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Int Joint Res Ctr Persistent Tox Subst, Harbin 150090, Peoples R China
第一作者单位中国科学院烟台海岸带研究所
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Liao, Chunyang,Liu, Fang,Alomirah, Husam,et al. Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2012,46(12):6860-6866.
APA Liao, Chunyang.,Liu, Fang.,Alomirah, Husam.,Vu Duc Loi.,Mohd, Mustafa Ali.,...&Kannan, Kurunthachalam.(2012).Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures.ENVIRONMENTAL SCIENCE & TECHNOLOGY,46(12),6860-6866.
MLA Liao, Chunyang,et al."Bisphenol S in Urine from the United States and Seven Asian Countries: Occurrence and Human Exposures".ENVIRONMENTAL SCIENCE & TECHNOLOGY 46.12(2012):6860-6866.
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