With benzo isothiazolin-3ketone as raw material, we have synthesized 4 novel derivatives, 3chloropropionyl chloridebenzene isothiazolone, propionyl chloridebenzene isothiazolone, acryloyl chloridebenzene isothiazolone and methyl acryloyl chloridebenzene isothiazolone. The four target compounds are analyzed by 1H NMR andmass spectrometry （MS） and the structures are confirmed. Antibacterial activity of the four compounds is also examined to the common microorganisms,including Escherichia coli, Bacillus subtilis and Staphylococcus aureus. The result shows that in lower concentrations （≤25 mg/L ）, the four compounds have the inhibitory rate of 80% above to Escherichia coli and Bacillus subtilis; the inhibitory rate is lower to Staphylococcus aureus, and only in a high concentration （≥ 50 mg/L ）, can they significantly inhibit the growthof Staphylococcus aureus.
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