| Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper | |
Zhang, Linbao1,2,4; Gan, Junli3; Ke, Changliang3; Liu, Xiaoli1,2,4; Zhao, Jianmin1,2 ; You, Liping1,2,4; Yu, Junbao1,2; Wu, Huifeng1,2
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| 发表期刊 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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| ISSN | 1382-6689 |
| 2012 | |
| 卷号 | 33期号:1页码:85-91 |
| 关键词 | Venerupis (Ruditapes) Philippinarum Cytochromes P450 Mrna Expression Benzo[a]Pyrene Heavy Metals Biomarker |
| 产权排序 | [Zhang, Linbao; Liu, Xiaoli; Zhao, Jianmin; You, Liping; Yu, Junbao; Wu, Huifeng] CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; Zhao, Jianmin; You, Liping; Yu, Junbao; Wu, Huifeng] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Gan, Junli; Ke, Changliang] Key Lab Fishery Ecol & Environm, Guangzhou 510300, Guangdong, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 通讯作者 | Zhao, JM (reprint author), CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. jmzhao@yic.ac.cn ; hfwu@yic.ac.cn |
| 作者部门 | 污染过程与控制实验室 |
| 英文摘要 | With the objective to identify promising molecular biomarkers for marine pollution monitoring, a new cytochrome P450 gene was identified from Venerupis (Ruditapes) philippinarum and classified as a member of a new subfamily, CYP414A1. Phylogenetic analysis showed that CYP414A1 was closely related to members of the CYP2 family. CYP414A1 mRNA expression was significantly induced by 50 mu g/L B[a]P at 96h, while no significant change was found in 5 mu g/L B[a]P-exposed samples. For heavy metals exposure, the expression of CYP414A1 was significantly up-regulated by Cd but sharply depressed by Cu exposure. These results suggested that CYP414A1 responded to various xenobiotics stresses, and could be used as a candidate biomarker of heavy metals and B[a]P.; With the objective to identify promising molecular biomarkers for marine pollution monitoring, a new cytochrome P450 gene was identified from Venerupis (Ruditapes) philippinarum and classified as a member of a new subfamily, CYP414A1. Phylogenetic analysis showed that CYP414A1 was closely related to members of the CYP2 family. CYP414A1 mRNA expression was significantly induced by 50 mu g/L B[a]P at 96h, while no significant change was found in 5 mu g/L B[a]P-exposed samples. For heavy metals exposure, the expression of CYP414A1 was significantly up-regulated by Cd but sharply depressed by Cu exposure. These results suggested that CYP414A1 responded to various xenobiotics stresses, and could be used as a candidate biomarker of heavy metals and B[a]P. (C) 2011 Elsevier B.V. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | Chinese Academy of Sciences[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; Key Lab of Fishery Ecology and Environment, Guangdong Province; CAS/SAFEA |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | TIDAL FLATS ; GENE ; MERCURY ; INDUCTION ; CLONING ; MUSSEL ; FISH ; P450 |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| WOS记录号 | WOS:000301876600011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/5609 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 中国科学院海岸带环境过程与生态修复重点实验室_滨海湿地实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Key Lab Fishery Ecol & Environm, Guangzhou 510300, Guangdong, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Linbao,Gan, Junli,Ke, Changliang,et al. Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2012,33(1):85-91. |
| APA | Zhang, Linbao.,Gan, Junli.,Ke, Changliang.,Liu, Xiaoli.,Zhao, Jianmin.,...&Wu, Huifeng.(2012).Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,33(1),85-91. |
| MLA | Zhang, Linbao,et al."Identification and expression profile of a new cytochrome P450 isoform (CYP414A1) in the hepatopancreas of Venerupis (Ruditapes) philippinarum exposed to benzo[a]pyrene, cadmium and copper".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 33.1(2012):85-91. |
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