| Sesquiterpenes and acetogenins from the marine red alga Laurencia okamurai | |
Li, Xiao-Dong1; Miao, Feng-Ping1 ; Li, Ke2; Ji, Nai-Yun1
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| 发表期刊 | FITOTERAPIA
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| ISSN | 0367-326X |
| 2012-04-01 | |
| 卷号 | 83期号:3页码:518-522 |
| 关键词 | Laurencia Okamurai Sesquiterpene Chamigrene Cuparane Acetogenin |
| 产权排序 | [Li, Xiao-Dong; Miao, Feng-Ping; Ji, Nai-Yun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Li, Ke] Michigan State Univ, E Lansing, MI 48824 USA |
| 通讯作者 | Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. nyji@yic.ac.cn |
| 作者部门 | 生物资源实验室 |
| 英文摘要 | Three new halogenated sesquiterpenes, 10-bromo-7 alpha,8 alpha-expoxychamigr-1-en-3-ol (1), 10-bromo-beta-chamigren-8-ol (2), and 10-bromo-3-chlorocupar-5-en-2-ol (3), one new C-12-acetogenin, desepilaurallene (7), one new naturally occurring sesquiterpene, 7-hydroxylaurene acetate (4), two known sesquiterpenes, allolaurinterol acetate (5) and laurene (6), and one known C-15-acetogenin, epilaurallene (8), were isolated from the marine red alga Laurencia okamurai collected from the coast of Rongcheng, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The bioassay results showed that 4,5 exhibited potent antibacterial activity, and 1, 4, 5 were toxic to brine shrimp.; Three new halogenated sesquiterpenes, 10-bromo-7 alpha,8 alpha-expoxychamigr-1-en-3-ol (1), 10-bromo-beta-chamigren-8-ol (2), and 10-bromo-3-chlorocupar-5-en-2-ol (3), one new C-12-acetogenin, desepilaurallene (7), one new naturally occurring sesquiterpene, 7-hydroxylaurene acetate (4), two known sesquiterpenes, allolaurinterol acetate (5) and laurene (6), and one known C-15-acetogenin, epilaurallene (8), were isolated from the marine red alga Laurencia okamurai collected from the coast of Rongcheng, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The bioassay results showed that 4,5 exhibited potent antibacterial activity, and 1, 4, 5 were toxic to brine shrimp. (C) 2011 Elsevier B.V. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China[41106136, 41106137]; Shandong Province Natural Science Foundation[ZR2009BQ021]; Chinese Academy of Sciences for Key Topics in Innovation Engineering[KZCX2-YW-QN209, KZCX2-YW-225]; Foundation of the Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | SECONDARY METABOLITES ; NIPPONICA YAMADA ; CONSTITUENTS ; DERIVATIVES ; PLANTS |
| 研究领域[WOS] | Pharmacology & Pharmacy |
| WOS记录号 | WOS:000302109400012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/5577 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Michigan State Univ, E Lansing, MI 48824 USA |
| 推荐引用方式 GB/T 7714 | Li, Xiao-Dong,Miao, Feng-Ping,Li, Ke,et al. Sesquiterpenes and acetogenins from the marine red alga Laurencia okamurai[J]. FITOTERAPIA,2012,83(3):518-522. |
| APA | Li, Xiao-Dong,Miao, Feng-Ping,Li, Ke,&Ji, Nai-Yun.(2012).Sesquiterpenes and acetogenins from the marine red alga Laurencia okamurai.FITOTERAPIA,83(3),518-522. |
| MLA | Li, Xiao-Dong,et al."Sesquiterpenes and acetogenins from the marine red alga Laurencia okamurai".FITOTERAPIA 83.3(2012):518-522. |
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