Secondary Metabolites from an Algicolous Aspergillus versicolor Strain | |
Miao, Feng-Ping1; Li, Xiao-Dong1; Liu, Xiang-Hong1; Cichewicz, Robert H.2; Ji, Nai-Yun1 | |
发表期刊 | MARINE DRUGS |
ISSN | 1660-3397 |
2012 | |
卷号 | 10期号:1页码:131-139 |
关键词 | Sargassum Thunbergii Aspergillus Versicolor Asperversin a 9 Xi-o-2(2 3-dimethylbut-3-enyl)Brevianamide q |
产权排序 | [Miao, Feng-Ping; Li, Xiao-Dong; Liu, Xiang-Hong; Ji, Nai-Yun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Cichewicz, Robert H.] Univ Oklahoma, Dept Chem & Biochem, Nat Prod Discovery Grp, Norman, OK 73019 USA |
通讯作者 | Ji, NY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. fpmiao@yic.ac.cn ; imnli@163.com ; xianghong1127@163.com ; rhcichewicz@ou.edu ; nyji@yic.ac.cn |
作者部门 | 生物资源实验室 |
英文摘要 | Two new compounds, asperversin A (1) and 9 xi-O-2(2,3-dimethylbut-3-enyl)brevianamide Q (2), and nine known compounds, brevianamide K (3), brevianamide M (4), aversin (5), 6,8-di-O-methylnidurufin (6), 6,8-di-O-methylaverufin (7), 6-O-methylaverufin (8), 5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (9), ergosta-7,22-diene-3 beta,5 alpha,6 beta-triol (10), and 6 beta-methoxyergosta-7,22-diene-3 beta,5 alpha-diol (11), were obtained from the culture of Aspergillus versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii. The structures of these compounds were established by spectroscopic techniques. Compounds 4, 7 and 8 exhibited antibacterial activities against Escherichia coli and Staphyloccocus aureus, and 7 also showed lethality against brine shrimp (Artemia salina) with an LC(50) value of 0.5 mu g/mL.; Two new compounds, asperversin A (1) and 9 xi-O-2(2,3-dimethylbut-3-enyl)brevianamide Q (2), and nine known compounds, brevianamide K (3), brevianamide M (4), aversin (5), 6,8-di-O-methylnidurufin (6), 6,8-di-O-methylaverufin (7), 6-O-methylaverufin (8), 5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (9), ergosta-7,22-diene-3 beta,5 alpha,6 beta-triol (10), and 6 beta-methoxyergosta-7,22-diene-3 beta,5 alpha-diol (11), were obtained from the culture of Aspergillus versicolor, an endophytic fungus isolated from the marine brown alga Sargassum thunbergii. The structures of these compounds were established by spectroscopic techniques. Compounds 4, 7 and 8 exhibited antibacterial activities against Escherichia coli and Staphyloccocus aureus, and 7 also showed lethality against brine shrimp (Artemia salina) with an LC(50) value of 0.5 mu g/mL. |
文章类型 | Article |
资助机构 | National Natural Science Foundation of China[41106137, 41106136]; Chinese Academy of Sciences[KZCX2-YW-QN209, KSCX2-EW-G-12B]; Foundation of the Chinese Academy of Sciences |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | ASSIGNMENTS |
研究领域[WOS] | Pharmacology & Pharmacy |
WOS记录号 | WOS:000299541800010 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/5575 |
专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Oklahoma, Dept Chem & Biochem, Nat Prod Discovery Grp, Norman, OK 73019 USA |
推荐引用方式 GB/T 7714 | Miao, Feng-Ping,Li, Xiao-Dong,Liu, Xiang-Hong,et al. Secondary Metabolites from an Algicolous Aspergillus versicolor Strain[J]. MARINE DRUGS,2012,10(1):131-139. |
APA | Miao, Feng-Ping,Li, Xiao-Dong,Liu, Xiang-Hong,Cichewicz, Robert H.,&Ji, Nai-Yun.(2012).Secondary Metabolites from an Algicolous Aspergillus versicolor Strain.MARINE DRUGS,10(1),131-139. |
MLA | Miao, Feng-Ping,et al."Secondary Metabolites from an Algicolous Aspergillus versicolor Strain".MARINE DRUGS 10.1(2012):131-139. |
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