Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae | |
Cui, Hongli1,2; Wang, Yipeng1; Zhang, Hongyu1,2; Wang, Yinchu1,2; Qin, Song1 | |
发表期刊 | PLANT MOLECULAR BIOLOGY REPORTER |
ISSN | 0735-9640 |
2012-04-01 | |
卷号 | 30期号:2页码:421-432 |
关键词 | Biotin Biosynthesis Molecular Evolution Coevolution Comparative Genomics Algae |
产权排序 | [Cui, Hongli; Wang, Yipeng; Zhang, Hongyu; Wang, Yinchu; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Cui, Hongli; Zhang, Hongyu; Wang, Yinchu] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
通讯作者 | Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. sqin@yic.ac.cn |
作者部门 | 生物资源实验室 |
英文摘要 | Biotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes, which play a significant role in various metabolic reactions such as fatty acid synthesis, branched chain amino acid catabolism, and gluconeogenesis. Biotin is also involved in citric acid cycle, which is the process of biochemical energy generation during aerobic respiration. Though the function of biotin in the growth of algae has been extensively investigated, little is known about the biosynthetic routes of biotin in the algal kingdom. In the present study, 44 biotin biosynthesis-related genes were identified from 14 eukaryotic photosynthetic algal genomes by BLASTP and TBLASN programs. A comprehensive analysis was performed to characterize distribution, phylogeny, structure domains, and coevolution patterns of those genes. Forty-four biotin biosynthesis-related enzymes (BBREs) were found to be distributed in three groups: 7-keto-8-aminopelargonic acid synthase, diaminopelargonic acid synthase/dethiobiotin synthetase, and biotin synthase. Structure domains were considerably conserved among the subfamilies of BBREs. The intramolecular coevolutionary sites are widely distributed in biotin synthase. The present study provides new insights into the origin and evolution of biotin biosynthetic pathways in eukaryotic photosynthetic algae. Furthermore, the characterization of biotin biosynthesis-related genes from algae will promote the identification and functional studies of BBREs.; Biotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes, which play a significant role in various metabolic reactions such as fatty acid synthesis, branched chain amino acid catabolism, and gluconeogenesis. Biotin is also involved in citric acid cycle, which is the process of biochemical energy generation during aerobic respiration. Though the function of biotin in the growth of algae has been extensively investigated, little is known about the biosynthetic routes of biotin in the algal kingdom. In the present study, 44 biotin biosynthesis-related genes were identified from 14 eukaryotic photosynthetic algal genomes by BLASTP and TBLASN programs. A comprehensive analysis was performed to characterize distribution, phylogeny, structure domains, and coevolution patterns of those genes. Forty-four biotin biosynthesis-related enzymes (BBREs) were found to be distributed in three groups: 7-keto-8-aminopelargonic acid synthase, diaminopelargonic acid synthase/dethiobiotin synthetase, and biotin synthase. Structure domains were considerably conserved among the subfamilies of BBREs. The intramolecular coevolutionary sites are widely distributed in biotin synthase. The present study provides new insights into the origin and evolution of biotin biosynthetic pathways in eukaryotic photosynthetic algae. Furthermore, the characterization of biotin biosynthesis-related genes from algae will promote the identification and functional studies of BBREs. |
文章类型 | Article |
资助机构 | National Natural Science Foundation of China[40876082]; Chinese Academy of Sciences; Outstanding Young Scholars Fellowship of Shandong Province (Molecular Phycology)[JQ200914] |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | SACCHAROMYCES-CEREVISIAE ; CYANIDIOSCHYZON-MEROLAE ; ARABIDOPSIS-THALIANA ; CAROTENOID BIOSYNTHESIS ; SYNTHASE REACTION ; ESCHERICHIA-COLI ; GENE-TRANSFER ; RED ALGAE ; EVOLUTION ; PLANTS |
研究领域[WOS] | Biochemistry & Molecular Biology ; Plant Sciences |
WOS记录号 | WOS:000301594300017 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/5553 |
专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Cui, Hongli,Wang, Yipeng,Zhang, Hongyu,et al. Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae[J]. PLANT MOLECULAR BIOLOGY REPORTER,2012,30(2):421-432. |
APA | Cui, Hongli,Wang, Yipeng,Zhang, Hongyu,Wang, Yinchu,&Qin, Song.(2012).Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae.PLANT MOLECULAR BIOLOGY REPORTER,30(2),421-432. |
MLA | Cui, Hongli,et al."Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae".PLANT MOLECULAR BIOLOGY REPORTER 30.2(2012):421-432. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Genome-Wide Analysis(713KB) | 开放获取 | -- | 浏览 请求全文 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论