Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae
Cui, Hongli1,2; Wang, Yipeng1; Zhang, Hongyu1,2; Wang, Yinchu1,2; Qin, Song1
发表期刊PLANT MOLECULAR BIOLOGY REPORTER
ISSN0735-9640
2012-04-01
卷号30期号:2页码:421-432
关键词Biotin Biosynthesis Molecular Evolution Coevolution Comparative Genomics Algae
产权排序[Cui, Hongli; Wang, Yipeng; Zhang, Hongyu; Wang, Yinchu; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Cui, Hongli; Zhang, Hongyu; Wang, Yinchu] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
通讯作者Qin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. sqin@yic.ac.cn
作者部门生物资源实验室 
英文摘要Biotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes, which play a significant role in various metabolic reactions such as fatty acid synthesis, branched chain amino acid catabolism, and gluconeogenesis. Biotin is also involved in citric acid cycle, which is the process of biochemical energy generation during aerobic respiration. Though the function of biotin in the growth of algae has been extensively investigated, little is known about the biosynthetic routes of biotin in the algal kingdom. In the present study, 44 biotin biosynthesis-related genes were identified from 14 eukaryotic photosynthetic algal genomes by BLASTP and TBLASN programs. A comprehensive analysis was performed to characterize distribution, phylogeny, structure domains, and coevolution patterns of those genes. Forty-four biotin biosynthesis-related enzymes (BBREs) were found to be distributed in three groups: 7-keto-8-aminopelargonic acid synthase, diaminopelargonic acid synthase/dethiobiotin synthetase, and biotin synthase. Structure domains were considerably conserved among the subfamilies of BBREs. The intramolecular coevolutionary sites are widely distributed in biotin synthase. The present study provides new insights into the origin and evolution of biotin biosynthetic pathways in eukaryotic photosynthetic algae. Furthermore, the characterization of biotin biosynthesis-related genes from algae will promote the identification and functional studies of BBREs.; Biotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes, which play a significant role in various metabolic reactions such as fatty acid synthesis, branched chain amino acid catabolism, and gluconeogenesis. Biotin is also involved in citric acid cycle, which is the process of biochemical energy generation during aerobic respiration. Though the function of biotin in the growth of algae has been extensively investigated, little is known about the biosynthetic routes of biotin in the algal kingdom. In the present study, 44 biotin biosynthesis-related genes were identified from 14 eukaryotic photosynthetic algal genomes by BLASTP and TBLASN programs. A comprehensive analysis was performed to characterize distribution, phylogeny, structure domains, and coevolution patterns of those genes. Forty-four biotin biosynthesis-related enzymes (BBREs) were found to be distributed in three groups: 7-keto-8-aminopelargonic acid synthase, diaminopelargonic acid synthase/dethiobiotin synthetase, and biotin synthase. Structure domains were considerably conserved among the subfamilies of BBREs. The intramolecular coevolutionary sites are widely distributed in biotin synthase. The present study provides new insights into the origin and evolution of biotin biosynthetic pathways in eukaryotic photosynthetic algae. Furthermore, the characterization of biotin biosynthesis-related genes from algae will promote the identification and functional studies of BBREs.
文章类型Article
资助机构National Natural Science Foundation of China[40876082]; Chinese Academy of Sciences; Outstanding Young Scholars Fellowship of Shandong Province (Molecular Phycology)[JQ200914]
收录类别SCI
语种英语
关键词[WOS]SACCHAROMYCES-CEREVISIAE ; CYANIDIOSCHYZON-MEROLAE ; ARABIDOPSIS-THALIANA ; CAROTENOID BIOSYNTHESIS ; SYNTHASE REACTION ; ESCHERICHIA-COLI ; GENE-TRANSFER ; RED ALGAE ; EVOLUTION ; PLANTS
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号WOS:000301594300017
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/5553
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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GB/T 7714
Cui, Hongli,Wang, Yipeng,Zhang, Hongyu,et al. Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae[J]. PLANT MOLECULAR BIOLOGY REPORTER,2012,30(2):421-432.
APA Cui, Hongli,Wang, Yipeng,Zhang, Hongyu,Wang, Yinchu,&Qin, Song.(2012).Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae.PLANT MOLECULAR BIOLOGY REPORTER,30(2),421-432.
MLA Cui, Hongli,et al."Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae".PLANT MOLECULAR BIOLOGY REPORTER 30.2(2012):421-432.
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