YIC-IR  > 海岸带生物学与生物资源保护实验室
Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae
Cui, Hongli1,2; Wang, Yipeng1; Zhang, Hongyu1,2; Wang, Yinchu1,2; Qin, Song1
2012-04-01
Source PublicationPLANT MOLECULAR BIOLOGY REPORTER
ISSN0735-9640
Volume30Issue:2Pages:421-432
Contribution Rank[Cui, Hongli; Wang, Yipeng; Zhang, Hongyu; Wang, Yinchu; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Cui, Hongli; Zhang, Hongyu; Wang, Yinchu] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
AbstractBiotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes, which play a significant role in various metabolic reactions such as fatty acid synthesis, branched chain amino acid catabolism, and gluconeogenesis. Biotin is also involved in citric acid cycle, which is the process of biochemical energy generation during aerobic respiration. Though the function of biotin in the growth of algae has been extensively investigated, little is known about the biosynthetic routes of biotin in the algal kingdom. In the present study, 44 biotin biosynthesis-related genes were identified from 14 eukaryotic photosynthetic algal genomes by BLASTP and TBLASN programs. A comprehensive analysis was performed to characterize distribution, phylogeny, structure domains, and coevolution patterns of those genes. Forty-four biotin biosynthesis-related enzymes (BBREs) were found to be distributed in three groups: 7-keto-8-aminopelargonic acid synthase, diaminopelargonic acid synthase/dethiobiotin synthetase, and biotin synthase. Structure domains were considerably conserved among the subfamilies of BBREs. The intramolecular coevolutionary sites are widely distributed in biotin synthase. The present study provides new insights into the origin and evolution of biotin biosynthetic pathways in eukaryotic photosynthetic algae. Furthermore, the characterization of biotin biosynthesis-related genes from algae will promote the identification and functional studies of BBREs.; Biotin is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes, which play a significant role in various metabolic reactions such as fatty acid synthesis, branched chain amino acid catabolism, and gluconeogenesis. Biotin is also involved in citric acid cycle, which is the process of biochemical energy generation during aerobic respiration. Though the function of biotin in the growth of algae has been extensively investigated, little is known about the biosynthetic routes of biotin in the algal kingdom. In the present study, 44 biotin biosynthesis-related genes were identified from 14 eukaryotic photosynthetic algal genomes by BLASTP and TBLASN programs. A comprehensive analysis was performed to characterize distribution, phylogeny, structure domains, and coevolution patterns of those genes. Forty-four biotin biosynthesis-related enzymes (BBREs) were found to be distributed in three groups: 7-keto-8-aminopelargonic acid synthase, diaminopelargonic acid synthase/dethiobiotin synthetase, and biotin synthase. Structure domains were considerably conserved among the subfamilies of BBREs. The intramolecular coevolutionary sites are widely distributed in biotin synthase. The present study provides new insights into the origin and evolution of biotin biosynthetic pathways in eukaryotic photosynthetic algae. Furthermore, the characterization of biotin biosynthesis-related genes from algae will promote the identification and functional studies of BBREs.
Corresponding AuthorQin, S (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. sqin@yic.ac.cn
KeywordBiotin Biosynthesis Molecular Evolution Coevolution Comparative Genomics Algae
Department生物资源实验室 
Subject AreaBiochemistry & Molecular Biology ; Plant Sciences
Funding OrganizationNational Natural Science Foundation of China[40876082]; Chinese Academy of Sciences; Outstanding Young Scholars Fellowship of Shandong Province (Molecular Phycology)[JQ200914]
URL查看原文
Indexed BySCI
WOS KeywordSACCHAROMYCES-CEREVISIAE ; CYANIDIOSCHYZON-MEROLAE ; ARABIDOPSIS-THALIANA ; CAROTENOID BIOSYNTHESIS ; SYNTHASE REACTION ; ESCHERICHIA-COLI ; GENE-TRANSFER ; RED ALGAE ; EVOLUTION ; PLANTS
SubtypeArticle
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Plant Sciences
WOS IDWOS:000301594300017
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/5553
Collection海岸带生物学与生物资源保护实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cui, Hongli,Wang, Yipeng,Zhang, Hongyu,et al. Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae[J]. PLANT MOLECULAR BIOLOGY REPORTER,2012,30(2):421-432.
APA Cui, Hongli,Wang, Yipeng,Zhang, Hongyu,Wang, Yinchu,&Qin, Song.(2012).Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae.PLANT MOLECULAR BIOLOGY REPORTER,30(2),421-432.
MLA Cui, Hongli,et al."Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic Photosynthetic Algae".PLANT MOLECULAR BIOLOGY REPORTER 30.2(2012):421-432.
Files in This Item: Download All
File Name/Size DocType Version Access License
Genome-Wide Analysis(713KB) 开放获取--View Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cui, Hongli]'s Articles
[Wang, Yipeng]'s Articles
[Zhang, Hongyu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cui, Hongli]'s Articles
[Wang, Yipeng]'s Articles
[Zhang, Hongyu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cui, Hongli]'s Articles
[Wang, Yipeng]'s Articles
[Zhang, Hongyu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Genome-Wide Analysis of Biotin Biosynthesis in Eukaryotic.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.