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Potentiometric sensor for sensitive and selective detection of heparin
Chen, Yan1,2; Liang, Rong Ning1; Qin, Wei1
2012-02-01
发表期刊CHINESE CHEMICAL LETTERS
ISSN1001-8417
卷号23期号:2页码:233-236
产权排序[Chen, Yan; Liang, Rong Ning; Qin, Wei] Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Chen, Yan] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
摘要A polymeric membrane ion-selective electrode for determination of heparin is described in this paper. Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin. The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate. The potentiometric response to the concentration of heparin is linear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL can be achieved.; A polymeric membrane ion-selective electrode for determination of heparin is described in this paper. Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin. The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate. The potentiometric response to the concentration of heparin is linear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL can be achieved. (C) 2011 Wei Qin. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
通讯作者Qin, W (reprint author), Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. wqin@yic.ac.cn
关键词Potentiometry Sensing Element Heparin Protamine Polyion Sensor
作者部门环境化学实验室 
学科领域Chemistry
项目资助者National Natural Science Foundation of China[41176081]; Outstanding Youth Natural Science Foundation of Shandong Province[JQ200814]; Taishan Scholar Program of Shandong Province[TS20081159]
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收录类别SCI
关键词[WOS]MEMBRANE-ELECTRODE ; BIOANALYTICAL APPLICATIONS ; ELECTROCHEMICAL SENSOR
文章类型Article
语种英语
WOS研究方向Chemistry
WOS记录号WOS:000299917200028
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被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/5528
专题环境化学实验室
作者单位1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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GB/T 7714
Chen, Yan,Liang, Rong Ning,Qin, Wei. Potentiometric sensor for sensitive and selective detection of heparin[J]. CHINESE CHEMICAL LETTERS,2012,23(2):233-236.
APA Chen, Yan,Liang, Rong Ning,&Qin, Wei.(2012).Potentiometric sensor for sensitive and selective detection of heparin.CHINESE CHEMICAL LETTERS,23(2),233-236.
MLA Chen, Yan,et al."Potentiometric sensor for sensitive and selective detection of heparin".CHINESE CHEMICAL LETTERS 23.2(2012):233-236.
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