Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics
Zhang, Linbao1,2; Liu, Xiaoli1,2; You, Liping1,2; Zhou, Di1,2; Yu, Junbao1; Zhao, Jianmin1; Feng, Jianghua3; Wu, Huifeng1
发表期刊CLEAN-SOIL AIR WATER
ISSN1863-0650
2011-11-01
卷号39期号:11页码:989-995
关键词Biomarker Cadmium Manila Clam Metabolomics Toxicological Effect
产权排序[Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Yu, Junbao; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China; [Feng, Jianghua] Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen, Peoples R China
通讯作者Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China
作者部门污染过程与控制实验室 
英文摘要Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.; Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.
文章类型Article
资助机构Chinese Academy of Sciences, NSFC[41106102]; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA
收录类别SCI
语种英语
关键词[WOS]MUSSEL MYTILUS-EDULIS ; GLUCOSE DEGRADATION ; TIDAL FLATS ; EXPOSURE ; BIOCHEMISTRY ; BIOSORPTION ; GALLOPROVINCIALIS ; TRANSFORMATION ; SPECTROSCOPY ; METABONOMICS
研究领域[WOS]Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Water Resources
WOS记录号WOS:000297642400022
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/5394
专题中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中国科学院海岸带环境过程与生态修复重点实验室_滨海湿地实验室
中国科学院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen, Peoples R China
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GB/T 7714
Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics[J]. CLEAN-SOIL AIR WATER,2011,39(11):989-995.
APA Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Yu, Junbao.,...&Wu, Huifeng.(2011).Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics.CLEAN-SOIL AIR WATER,39(11),989-995.
MLA Zhang, Linbao,et al."Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics".CLEAN-SOIL AIR WATER 39.11(2011):989-995.
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