Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics | |
Zhang, Linbao1,2; Liu, Xiaoli1,2; You, Liping1,2; Zhou, Di1,2; Yu, Junbao1; Zhao, Jianmin1; Feng, Jianghua3; Wu, Huifeng1 | |
发表期刊 | CLEAN-SOIL AIR WATER |
ISSN | 1863-0650 |
2011-11-01 | |
卷号 | 39期号:11页码:989-995 |
关键词 | Biomarker Cadmium Manila Clam Metabolomics Toxicological Effect |
产权排序 | [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Yu, Junbao; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China; [Feng, Jianghua] Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen, Peoples R China |
通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China |
作者部门 | 污染过程与控制实验室 |
英文摘要 | Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.; Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator. |
文章类型 | Article |
资助机构 | Chinese Academy of Sciences, NSFC[41106102]; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | MUSSEL MYTILUS-EDULIS ; GLUCOSE DEGRADATION ; TIDAL FLATS ; EXPOSURE ; BIOCHEMISTRY ; BIOSORPTION ; GALLOPROVINCIALIS ; TRANSFORMATION ; SPECTROSCOPY ; METABONOMICS |
研究领域[WOS] | Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Water Resources |
WOS记录号 | WOS:000297642400022 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/5394 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_滨海湿地实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics[J]. CLEAN-SOIL AIR WATER,2011,39(11):989-995. |
APA | Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Yu, Junbao.,...&Wu, Huifeng.(2011).Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics.CLEAN-SOIL AIR WATER,39(11),989-995. |
MLA | Zhang, Linbao,et al."Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics".CLEAN-SOIL AIR WATER 39.11(2011):989-995. |
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