Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics
Zhang, Linbao1,2; Liu, Xiaoli1,2; You, Liping1,2; Zhou, Di1,2; Yu, Junbao1; Zhao, Jianmin1; Feng, Jianghua3; Wu, Huifeng1
Source PublicationCLEAN-SOIL AIR WATER
ISSN1863-0650
2011-11-01
Volume39Issue:11Pages:989-995
KeywordBiomarker Cadmium Manila Clam Metabolomics Toxicological Effect
Contribution Rank[Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Yu, Junbao; Zhao, Jianmin; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China; [Feng, Jianghua] Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen, Peoples R China
Corresponding AuthorWu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China
Department污染过程与控制实验室 
AbstractCadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.; Cadmium (Cd) has become an important heavy metal contaminant in the sediment and seawater along the Bohai Sea and been of great ecological risk due to its toxic effects to marine organisms. In this work, the toxicological effects caused by environmentally relevant concentrations (10 and 40 mu g L(-1)) of Cd were studied in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48, and 96 h. Both low (10 mu g L(-1)) and high (40 mu g L(-1)) doses of Cd caused the disturbances in energy metabolism and osmotic regulation and neurotoxicity based on the metabolic biomarkers such as succinate, alanine, branched chain amino acids, betaine, hypotaurine, and glutamate in clam gills after 24 h of exposure. However, the recovery of toxicological effects of Cd after exposure for 96 h was obviously observed in clam to Cd exposures. Overall, these results indicated that NMR-based metabolomics was applicable to elucidate the toxicological effects of heavy metal contaminants in the marine bioindicator.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordMUSSEL MYTILUS-EDULIS ; GLUCOSE DEGRADATION ; TIDAL FLATS ; EXPOSURE ; BIOCHEMISTRY ; BIOSORPTION ; GALLOPROVINCIALIS ; TRANSFORMATION ; SPECTROSCOPY ; METABONOMICS
WOS Research AreaEnvironmental Sciences & Ecology ; Marine & Freshwater Biology ; Water Resources
WOS IDWOS:000297642400022
Funding OrganizationChinese Academy of Sciences, NSFC[41106102]; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/5394
Collection中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, CAS Shandong Prov Key Lab Coastal Zone Environm P, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
3.Xiamen Univ, Dept Elect Sci, Fujian Key Lab Plasma & Magnet Resonance, State Key Lab Phys Chem Solid Surfaces, Xiamen, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics[J]. CLEAN-SOIL AIR WATER,2011,39(11):989-995.
APA Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Yu, Junbao.,...&Wu, Huifeng.(2011).Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics.CLEAN-SOIL AIR WATER,39(11),989-995.
MLA Zhang, Linbao,et al."Toxicological Effects Induced by Cadmium in Gills of Manila Clam Ruditapes philippinarum Using NMR-Based Metabolomics".CLEAN-SOIL AIR WATER 39.11(2011):989-995.
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