Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics
Zhang, Linbao1,2,3; Liu, Xiaoli1,2,3; You, Liping1,2,3; Zhou, Di1,2,3; Wu, Huifeng1,2; Li, Lianzhen1,2; Zhao, Jianmin1,2; Feng, Jianghua4; Yu, Junbao1,2
发表期刊MARINE ENVIRONMENTAL RESEARCH
ISSN0141-1136
2011-07-01
卷号72期号:1-2页码:33-39
关键词Copper Heavy Metal Toxicity Metabolites Biomarkers Manila Clam Bioindicator Metabolomics
产权排序[Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Wu, Huifeng; Li, Lianzhen; Zhao, Jianmin; Yu, Junbao] CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Wu, Huifeng; Li, Lianzhen; Zhao, Jianmin; Yu, Junbao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; [Feng, Jianghua] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Fujian Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China
通讯作者Wu, HF (reprint author), CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
作者部门污染过程与控制实验室 
英文摘要Copper is an important heavy metal contaminant with high ecological risk in the Bohai Sea. In this study, the metabolic responses in the bioindicator, Manila clam (Ruditapes philippinarum), to the environmentally relevant copper exposures were characterized using NMR-based metabolomics. The significant metabolic changes corresponding to copper exposures were related to osmolytes, intermediates of the Krebs cycle and amino acids, such as the increase in homarine, branched chain amino acids and decrease in succinate, alanine and dimethylamine in the copper-exposed clam gills during 96 h exposure period. Overall, Cu may lead to the disturbances in osmotic regulation and energy metabolism in clams during 96 h experimental period. These results demonstrate that NMR-based metabolomics is applicable for the discovery of metabolic biomarkers which could be used to elucidate the toxicological mechanisms of marine heavy metal contaminants. (C) 2011 Elsevier Ltd. All rights reserved.; Copper is an important heavy metal contaminant with high ecological risk in the Bohai Sea. In this study, the metabolic responses in the bioindicator, Manila clam (Ruditapes philippinarum), to the environmentally relevant copper exposures were characterized using NMR-based metabolomics. The significant metabolic changes corresponding to copper exposures were related to osmolytes, intermediates of the Krebs cycle and amino acids, such as the increase in homarine, branched chain amino acids and decrease in succinate, alanine and dimethylamine in the copper-exposed clam gills during 96 h exposure period. Overall, Cu may lead to the disturbances in osmotic regulation and energy metabolism in clams during 96 h experimental period. These results demonstrate that NMR-based metabolomics is applicable for the discovery of metabolic biomarkers which could be used to elucidate the toxicological mechanisms of marine heavy metal contaminants. (C) 2011 Elsevier Ltd. All rights reserved.
文章类型Article
资助机构Chinese Academy of Sciences[KZCX2-YW-Q07-04]; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA
收录类别SCI
语种英语
关键词[WOS]MAGNETIC-RESONANCE-SPECTROSCOPY ; MUSSEL MYTILUS-EDULIS ; PATTERN-RECOGNITION ; H-1-NMR METABOLOMICS ; TIDAL FLATS ; LIVER ; EXTRACTION ; POLLUTION ; DISEASE ; GALLOPROVINCIALIS
研究领域[WOS]Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology
WOS记录号WOS:000295349300005
引用统计
被引频次:99[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/5376
专题中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中国科学院海岸带环境过程与生态修复重点实验室_滨海湿地实验室
中国科学院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Fujian Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China
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GB/T 7714
Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics[J]. MARINE ENVIRONMENTAL RESEARCH,2011,72(1-2):33-39.
APA Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Wu, Huifeng.,...&Yu, Junbao.(2011).Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics.MARINE ENVIRONMENTAL RESEARCH,72(1-2),33-39.
MLA Zhang, Linbao,et al."Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics".MARINE ENVIRONMENTAL RESEARCH 72.1-2(2011):33-39.
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