Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics | |
Zhang, Linbao1,2,3; Liu, Xiaoli1,2,3; You, Liping1,2,3; Zhou, Di1,2,3; Wu, Huifeng1,2; Li, Lianzhen1,2; Zhao, Jianmin1,2; Feng, Jianghua4; Yu, Junbao1,2 | |
发表期刊 | MARINE ENVIRONMENTAL RESEARCH |
ISSN | 0141-1136 |
2011-07-01 | |
卷号 | 72期号:1-2页码:33-39 |
关键词 | Copper Heavy Metal Toxicity Metabolites Biomarkers Manila Clam Bioindicator Metabolomics |
产权排序 | [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Wu, Huifeng; Li, Lianzhen; Zhao, Jianmin; Yu, Junbao] CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Wu, Huifeng; Li, Lianzhen; Zhao, Jianmin; Yu, Junbao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China; [Feng, Jianghua] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Fujian Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China |
通讯作者 | Wu, HF (reprint author), CAS, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China |
作者部门 | 污染过程与控制实验室 |
英文摘要 | Copper is an important heavy metal contaminant with high ecological risk in the Bohai Sea. In this study, the metabolic responses in the bioindicator, Manila clam (Ruditapes philippinarum), to the environmentally relevant copper exposures were characterized using NMR-based metabolomics. The significant metabolic changes corresponding to copper exposures were related to osmolytes, intermediates of the Krebs cycle and amino acids, such as the increase in homarine, branched chain amino acids and decrease in succinate, alanine and dimethylamine in the copper-exposed clam gills during 96 h exposure period. Overall, Cu may lead to the disturbances in osmotic regulation and energy metabolism in clams during 96 h experimental period. These results demonstrate that NMR-based metabolomics is applicable for the discovery of metabolic biomarkers which could be used to elucidate the toxicological mechanisms of marine heavy metal contaminants. (C) 2011 Elsevier Ltd. All rights reserved.; Copper is an important heavy metal contaminant with high ecological risk in the Bohai Sea. In this study, the metabolic responses in the bioindicator, Manila clam (Ruditapes philippinarum), to the environmentally relevant copper exposures were characterized using NMR-based metabolomics. The significant metabolic changes corresponding to copper exposures were related to osmolytes, intermediates of the Krebs cycle and amino acids, such as the increase in homarine, branched chain amino acids and decrease in succinate, alanine and dimethylamine in the copper-exposed clam gills during 96 h exposure period. Overall, Cu may lead to the disturbances in osmotic regulation and energy metabolism in clams during 96 h experimental period. These results demonstrate that NMR-based metabolomics is applicable for the discovery of metabolic biomarkers which could be used to elucidate the toxicological mechanisms of marine heavy metal contaminants. (C) 2011 Elsevier Ltd. All rights reserved. |
文章类型 | Article |
资助机构 | Chinese Academy of Sciences[KZCX2-YW-Q07-04]; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | MAGNETIC-RESONANCE-SPECTROSCOPY ; MUSSEL MYTILUS-EDULIS ; PATTERN-RECOGNITION ; H-1-NMR METABOLOMICS ; TIDAL FLATS ; LIVER ; EXTRACTION ; POLLUTION ; DISEASE ; GALLOPROVINCIALIS |
研究领域[WOS] | Environmental Sciences & Ecology ; Marine & Freshwater Biology ; Toxicology |
WOS记录号 | WOS:000295349300005 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/5376 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_滨海湿地实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
作者单位 | 1.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Fujian Key Lab Plasma & Magnet Resonance, Dept Elect Sci, Xiamen 361005, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Linbao,Liu, Xiaoli,You, Liping,et al. Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics[J]. MARINE ENVIRONMENTAL RESEARCH,2011,72(1-2):33-39. |
APA | Zhang, Linbao.,Liu, Xiaoli.,You, Liping.,Zhou, Di.,Wu, Huifeng.,...&Yu, Junbao.(2011).Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics.MARINE ENVIRONMENTAL RESEARCH,72(1-2),33-39. |
MLA | Zhang, Linbao,et al."Metabolic responses in gills of Manila clam Ruditapes philippinarum exposed to copper using NMR-based metabolomics".MARINE ENVIRONMENTAL RESEARCH 72.1-2(2011):33-39. |
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