Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice
Zhang, Hongyu2; Yi, Yuetao1; Feng, Dawei; Wang, Yipeng; Qin, Song1
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
2011
Volume.Pages:1-7
KeywordVanadyl Sulfate Insulin Sensitivity Blood-glucose In-vivo Rats Complexes Mellitus Oxidation Systems
DOI10.1155/2011/691067
Contribution Rank[Yi, Yuetao; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China; [Zhang, Hongyu] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Corresponding AuthorYi, YT (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China
Department生物资源实验室 
AbstractIn order to avoid low absorption, incorporation, and undesirable side effects of inorganic oxovanadium compounds, the antidiabetic activities of organic oxovanadium (IV) compounds in alloxan-induced diabetic mice were investigated. Vanadyl carboxymethyl carrageenan (VOCCA) and vanadyl carboxymethyl chitosan (VOCCH) were synthesized and administrated through intragastric administration in different doses for 20 days in alloxan-induced diabetic mice. Glibenclamide was administrated as the positive control. Our results showed that low-dose group, middle-dose group, and high-dose group of VOCCA and VOCCH could significantly reduce the levels of blood glucose (P < 0.05) compared with untreated group, but not in normal mice. Besides, high-dose groups of VOCCA and VOCCH exhibited more significant hypoglycemic activities (P < 0.01). After treated with VOCCH, the oral glucose tolerance of high-dose group of VOCCH was improved compared with model control group (P < 0.05).
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordVANADYL SULFATE ; INSULIN SENSITIVITY ; BLOOD-GLUCOSE ; IN-VIVO ; RATS ; COMPLEXES ; MELLITUS ; OXIDATION ; SYSTEMS
WOS Research AreaIntegrative & Complementary Medicine
WOS IDWOS:000293527800001
Funding OrganizationChinese Academy of Sciences[KZCX2-YW-225]; Science & Technology Development Plan of Shandong Province[2010GSF10208]; CAS/SAFEA ; Chinese Academy of Sciences KZCX2-YW-225 ; Science & Technology Development Plan of Shandong Province 2010GSF10208 ; CAS/SAFEA
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/5352
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Hongyu,Yi, Yuetao,Feng, Dawei,et al. Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2011,.:1-7.
APA Zhang, Hongyu,Yi, Yuetao,Feng, Dawei,Wang, Yipeng,&Qin, Song.(2011).Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,.,1-7.
MLA Zhang, Hongyu,et al."Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE .(2011):1-7.
Files in This Item: Download All
File Name/Size DocType Version Access License
Hypoglycemic Propert(1004KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, Hongyu]'s Articles
[Yi, Yuetao]'s Articles
[Feng, Dawei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, Hongyu]'s Articles
[Yi, Yuetao]'s Articles
[Feng, Dawei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, Hongyu]'s Articles
[Yi, Yuetao]'s Articles
[Feng, Dawei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.