| Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice | |
Zhang, Hongyu2; Yi, Yuetao1 ; Feng, Dawei; Wang, Yipeng; Qin, Song1
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| Source Publication | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| ISSN | 1741-427X |
| 2011 | |
| Volume | .Pages:1-7 |
| Keyword | Vanadyl Sulfate Insulin Sensitivity Blood-glucose In-vivo Rats Complexes Mellitus Oxidation Systems |
| DOI | 10.1155/2011/691067 |
| Contribution Rank | [Yi, Yuetao; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China; [Zhang, Hongyu] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| Corresponding Author | Yi, YT (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China |
| Department | 生物资源实验室 |
| Abstract | In order to avoid low absorption, incorporation, and undesirable side effects of inorganic oxovanadium compounds, the antidiabetic activities of organic oxovanadium (IV) compounds in alloxan-induced diabetic mice were investigated. Vanadyl carboxymethyl carrageenan (VOCCA) and vanadyl carboxymethyl chitosan (VOCCH) were synthesized and administrated through intragastric administration in different doses for 20 days in alloxan-induced diabetic mice. Glibenclamide was administrated as the positive control. Our results showed that low-dose group, middle-dose group, and high-dose group of VOCCA and VOCCH could significantly reduce the levels of blood glucose (P < 0.05) compared with untreated group, but not in normal mice. Besides, high-dose groups of VOCCA and VOCCH exhibited more significant hypoglycemic activities (P < 0.01). After treated with VOCCH, the oral glucose tolerance of high-dose group of VOCCH was improved compared with model control group (P < 0.05). |
| Subtype | Article |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | VANADYL SULFATE ; INSULIN SENSITIVITY ; BLOOD-GLUCOSE ; IN-VIVO ; RATS ; COMPLEXES ; MELLITUS ; OXIDATION ; SYSTEMS |
| WOS Research Area | Integrative & Complementary Medicine |
| WOS ID | WOS:000293527800001 |
| Funding Organization | Chinese Academy of Sciences[KZCX2-YW-225]; Science & Technology Development Plan of Shandong Province[2010GSF10208]; CAS/SAFEA ; Chinese Academy of Sciences KZCX2-YW-225 ; Science & Technology Development Plan of Shandong Province 2010GSF10208 ; CAS/SAFEA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/5352 |
| Collection | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Biol Resources Lab, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Hongyu,Yi, Yuetao,Feng, Dawei,et al. Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2011,.:1-7. |
| APA | Zhang, Hongyu,Yi, Yuetao,Feng, Dawei,Wang, Yipeng,&Qin, Song.(2011).Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,.,1-7. |
| MLA | Zhang, Hongyu,et al."Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE .(2011):1-7. |
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| Hypoglycemic Propert（1004KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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