Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics
Liu, Xiaoli1,2,3; Yang, Cuiyun1,2; Zhang, Linbao1,2,3; Li, Lianzhen1,2; Liu, Sujing1,2; Yu, Junbao1,2; You, Liping1,2,3; Zhou, Di1,2,3; Xia, Chuanhai1,2; Zhao, Jianmin1,2; Wu, Huifeng1,2
Source PublicationECOTOXICOLOGY
ISSN0963-9292
2011-08-01
Volume20Issue:6Pages:1422-1431
KeywordCadmium Suaeda Salsa Nmr Metabolomics
Contribution Rank[Liu, XL; Yang, CY; Zhang, LB; Li, LZ; Liu, SJ; Yu, JB; You, LP; Zhou, D; Xia, CH; Zhao, JM; Wu, HF] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Liu, XL; Yang, CY; Zhang, LB; Li, LZ; Liu, SJ; Yu, JB; You, LP; Zhou, D; Xia, CH; Zhao, JM; Wu, HF] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Liu, XL; Zhang, LB; You, LP; Zhou, D] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Corresponding AuthorWu, HF, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn
Department污染过程与控制实验室 
AbstractCadmium is a non-essential element to living organisms and has become the severe contaminant in both seawater and sediment in the intertidal zones of the Bohai Sea. The halophyte, Suaeda salsa is the pioneer plant in the intertidal zones of Bohai Sea and has been widely applied in environmental sciences. In this study, the dose- and time-dependent effects induced by environmentally relevant concentrations (2, 10 and 50 mu g l(-1)) of cadmium were characterized in S. salsa using NMR-based metabolomics. The levels of amino acids (valine, leucine, glutamate, tyrosine, etc.), carbohydrates (glucose, sucrose and fructose), intermediates of tricarboxylic acid cycle (succinate, citrate, etc.) and osmolyte (betaine) were altered in the S. salsa samples after cadmium exposures. These metabolic biomarkers indicated the elevated protein degradation and disturbances in the osmotic regulation and energy metabolism caused by cadmium in S. salsa. Overall, our results demonstrated the applicability of NMR-based metabolomics for the detection of metabolic biomarkers that could be used for the interpretation of toxicological effects induced by contaminants in the pioneer plant S. salsa in the intertidal zones. In addition, the metabolic biomarkers could be potentially useful for the bio-monitoring of contaminants in the intertidal zones.; Cadmium is a non-essential element to living organisms and has become the severe contaminant in both seawater and sediment in the intertidal zones of the Bohai Sea. The halophyte, Suaeda salsa is the pioneer plant in the intertidal zones of Bohai Sea and has been widely applied in environmental sciences. In this study, the dose- and time-dependent effects induced by environmentally relevant concentrations (2, 10 and 50 mu g l(-1)) of cadmium were characterized in S. salsa using NMR-based metabolomics. The levels of amino acids (valine, leucine, glutamate, tyrosine, etc.), carbohydrates (glucose, sucrose and fructose), intermediates of tricarboxylic acid cycle (succinate, citrate, etc.) and osmolyte (betaine) were altered in the S. salsa samples after cadmium exposures. These metabolic biomarkers indicated the elevated protein degradation and disturbances in the osmotic regulation and energy metabolism caused by cadmium in S. salsa. Overall, our results demonstrated the applicability of NMR-based metabolomics for the detection of metabolic biomarkers that could be used for the interpretation of toxicological effects induced by contaminants in the pioneer plant S. salsa in the intertidal zones. In addition, the metabolic biomarkers could be potentially useful for the bio-monitoring of contaminants in the intertidal zones.
Funding OrganizationProject of National Science & Technology Pillar Program in "12th Five Year'' Period[2011BAC02B01]; Chinese Academy of Sciences[KZCX2-YW-223, KZCX2-YW-225]; Technology Development Program Projects of Shandong Province[2008GG2000 5006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA International; Shandong Provincial Key Laboratory of Ecology and Environment in Yellow River Delta[2009KFJJ03]
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordV-H+-ATPASE ; SAMPLE-PREPARATION ; OXIDATIVE STRESS ; OSMOTIC-STRESS ; EXPOSURE ; LEAVES ; RESPONSES ; NACL ; TRANSFORMATION ; ACCUMULATION
WOS Research AreaEnvironmental Sciences & Ecology ; Toxicology
WOS IDWOS:000292689400024
Citation statistics
Cited Times:41[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/5119
Collection中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
中科院海岸带环境过程与生态修复重点实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xiaoli,Yang, Cuiyun,Zhang, Linbao,et al. Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics[J]. ECOTOXICOLOGY,2011,20(6):1422-1431.
APA Liu, Xiaoli.,Yang, Cuiyun.,Zhang, Linbao.,Li, Lianzhen.,Liu, Sujing.,...&Wu, Huifeng.(2011).Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics.ECOTOXICOLOGY,20(6),1422-1431.
MLA Liu, Xiaoli,et al."Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics".ECOTOXICOLOGY 20.6(2011):1422-1431.
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