| Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics | |
Liu, Xiaoli1,2,3; Yang, Cuiyun1,2 ; Zhang, Linbao1,2,3; Li, Lianzhen1,2; Liu, Sujing1,2; Yu, Junbao1,2; You, Liping1,2,3; Zhou, Di1,2,3; Xia, Chuanhai1,2; Zhao, Jianmin1,2; Wu, Huifeng1,2
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| 发表期刊 | ECOTOXICOLOGY
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| ISSN | 0963-9292 |
| 2011-08-01 | |
| 卷号 | 20期号:6页码:1422-1431 |
| 关键词 | Cadmium Suaeda Salsa Nmr Metabolomics |
| 产权排序 | [Liu, XL; Yang, CY; Zhang, LB; Li, LZ; Liu, SJ; Yu, JB; You, LP; Zhou, D; Xia, CH; Zhao, JM; Wu, HF] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Liu, XL; Yang, CY; Zhang, LB; Li, LZ; Liu, SJ; Yu, JB; You, LP; Zhou, D; Xia, CH; Zhao, JM; Wu, HF] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Liu, XL; Zhang, LB; You, LP; Zhou, D] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 通讯作者 | Wu, HF, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China. hfwu@yic.ac.cn |
| 作者部门 | 污染过程与控制实验室 |
| 英文摘要 | Cadmium is a non-essential element to living organisms and has become the severe contaminant in both seawater and sediment in the intertidal zones of the Bohai Sea. The halophyte, Suaeda salsa is the pioneer plant in the intertidal zones of Bohai Sea and has been widely applied in environmental sciences. In this study, the dose- and time-dependent effects induced by environmentally relevant concentrations (2, 10 and 50 mu g l(-1)) of cadmium were characterized in S. salsa using NMR-based metabolomics. The levels of amino acids (valine, leucine, glutamate, tyrosine, etc.), carbohydrates (glucose, sucrose and fructose), intermediates of tricarboxylic acid cycle (succinate, citrate, etc.) and osmolyte (betaine) were altered in the S. salsa samples after cadmium exposures. These metabolic biomarkers indicated the elevated protein degradation and disturbances in the osmotic regulation and energy metabolism caused by cadmium in S. salsa. Overall, our results demonstrated the applicability of NMR-based metabolomics for the detection of metabolic biomarkers that could be used for the interpretation of toxicological effects induced by contaminants in the pioneer plant S. salsa in the intertidal zones. In addition, the metabolic biomarkers could be potentially useful for the bio-monitoring of contaminants in the intertidal zones.; Cadmium is a non-essential element to living organisms and has become the severe contaminant in both seawater and sediment in the intertidal zones of the Bohai Sea. The halophyte, Suaeda salsa is the pioneer plant in the intertidal zones of Bohai Sea and has been widely applied in environmental sciences. In this study, the dose- and time-dependent effects induced by environmentally relevant concentrations (2, 10 and 50 mu g l(-1)) of cadmium were characterized in S. salsa using NMR-based metabolomics. The levels of amino acids (valine, leucine, glutamate, tyrosine, etc.), carbohydrates (glucose, sucrose and fructose), intermediates of tricarboxylic acid cycle (succinate, citrate, etc.) and osmolyte (betaine) were altered in the S. salsa samples after cadmium exposures. These metabolic biomarkers indicated the elevated protein degradation and disturbances in the osmotic regulation and energy metabolism caused by cadmium in S. salsa. Overall, our results demonstrated the applicability of NMR-based metabolomics for the detection of metabolic biomarkers that could be used for the interpretation of toxicological effects induced by contaminants in the pioneer plant S. salsa in the intertidal zones. In addition, the metabolic biomarkers could be potentially useful for the bio-monitoring of contaminants in the intertidal zones. |
| 文章类型 | Article |
| 资助机构 | Project of National Science & Technology Pillar Program in "12th Five Year'' Period[2011BAC02B01]; Chinese Academy of Sciences[KZCX2-YW-223, KZCX2-YW-225]; Technology Development Program Projects of Shandong Province[2008GG2000 5006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA International; Shandong Provincial Key Laboratory of Ecology and Environment in Yellow River Delta[2009KFJJ03] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | V-H+-ATPASE ; SAMPLE-PREPARATION ; OXIDATIVE STRESS ; OSMOTIC-STRESS ; EXPOSURE ; LEAVES ; RESPONSES ; NACL ; TRANSFORMATION ; ACCUMULATION |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Toxicology |
| WOS记录号 | WOS:000292689400024 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/5119 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 中国科学院海岸带环境过程与生态修复重点实验室_滨海湿地实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xiaoli,Yang, Cuiyun,Zhang, Linbao,et al. Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics[J]. ECOTOXICOLOGY,2011,20(6):1422-1431. |
| APA | Liu, Xiaoli.,Yang, Cuiyun.,Zhang, Linbao.,Li, Lianzhen.,Liu, Sujing.,...&Wu, Huifeng.(2011).Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics.ECOTOXICOLOGY,20(6),1422-1431. |
| MLA | Liu, Xiaoli,et al."Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics".ECOTOXICOLOGY 20.6(2011):1422-1431. |
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