A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain
Liu, Xiang-Hong1,2; Tang, Xiao-Zhen2; Miao, Feng-Ping1; Ji, Nai-Yun1
2011-09-01
发表期刊NATURAL PRODUCT COMMUNICATIONS
ISSN1934-578X
卷号6期号:9页码:1243-1246
产权排序[Liu, XH; Miao, FP; Ji, NY] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Liu, XH; Tang, XZ] Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China
摘要A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.; A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.
通讯作者Ji, NY, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. nyji@yic.ac.cn
关键词3-hydroxy-5-(Hydroxymethyl)-4-(4 '-hydroxyphenoxy)Pyrrolidin-2-one Gibberella Zeae Fusarium Graminearum Codium Fragile
作者部门生物资源实验室 
学科领域Pharmacology & Pharmacy ; Food Science & Technology
项目资助者Chinese Academy of Sciences for Key Topics in Innovation Engineering[KZCX2-YW-QN209, KSCX2-EW-G-12B]; Shandong Province Natural Science Foundation[ZR2009BQ021]; Yantai Municipal Sci-Tech Development Program[2009164]; Foundation of the Chinese Academy of Sciences
收录类别SCI
关键词[WOS]FUSARIUM-ROSEUM ATCC-28114 ; MINOR METABOLITES ; FRUIT BODIES ; CONSTITUENTS ; GRAMINEARUM
文章类型Article
语种英语
WOS研究方向Pharmacology & Pharmacy ; Food Science & Technology
WOS记录号WOS:000294381500008
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/5113
专题海岸带生物学与生物资源利用所重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China
第一作者单位中国科学院烟台海岸带研究所
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Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,et al. A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain[J]. NATURAL PRODUCT COMMUNICATIONS,2011,6(9):1243-1246.
APA Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,&Ji, Nai-Yun.(2011).A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain.NATURAL PRODUCT COMMUNICATIONS,6(9),1243-1246.
MLA Liu, Xiang-Hong,et al."A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain".NATURAL PRODUCT COMMUNICATIONS 6.9(2011):1243-1246.
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