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Title:
A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain
Author: Liu, Xiang-Hong1,2; Tang, Xiao-Zhen2; Miao, Feng-Ping1; Nai-Yun Ji(季乃云)1
Source: NATURAL PRODUCT COMMUNICATIONS
ISSN: 1934-578X
Issued Date: 2011-09-01
Volume: 6, Issue:9, Pages:1243-1246
Keyword: 3-hydroxy-5-(hydroxymethyl)-4-(4 '-hydroxyphenoxy)pyrrolidin-2-one ; Gibberella zeae ; Fusarium graminearum ; Codium fragile
Subject: Pharmacology & Pharmacy; Food Science & Technology
Rank: [Liu, XH; Miao, FP; Ji, NY] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Liu, XH; Tang, XZ] Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China
Corresponding Author: Ji, NY, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. nyji@yic.ac.cn
Department: 生物资源实验室 
Abstract: A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.
English Abstract: A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.
WOS Subject Extended: Pharmacology & Pharmacy ; Food Science & Technology
WOS Keyword Plus: FUSARIUM-ROSEUM ATCC-28114 ; MINOR METABOLITES ; FRUIT BODIES ; CONSTITUENTS ; GRAMINEARUM
DOC Type: Article
Indexed Type: SCI
Language: 英语
WOS ID: WOS:000294381500008
Citation statistics:
Content Type: 期刊论文
URI: http://ir.yic.ac.cn/handle/133337/5114
Appears in Collections:海岸带生物学与生物资源利用所重点实验室_期刊论文

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description.institution: 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China

Recommended Citation:
Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,et al. A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain[J]. NATURAL PRODUCT COMMUNICATIONS,2011,6(9):1243-1246.
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