A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain

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	A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain
	Liu, Xiang-Hong 1,2; Tang, Xiao-Zhen 2; Miao, Feng-Ping1 ; Ji, Nai-Yun1
发表期刊	NATURAL PRODUCT COMMUNICATIONS
ISSN	1934-578X
	2011-09-01
卷号	6 期号:9 页码:1243-1246
关键词	3-hydroxy-5-(Hydroxymethyl)-4-(4 '-hydroxyphenoxy)Pyrrolidin-2-one Gibberella Zeae Fusarium Graminearum Codium Fragile
产权排序	[Liu, XH; Miao, FP; Ji, NY] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Liu, XH; Tang, XZ] Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China
通讯作者	Ji, NY, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. nyji@yic.ac.cn
作者部门	生物资源实验室
英文摘要	A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.; A new pyrrolidine derivative, 3-hydroxy-5-(hydroxymethyl)-4-(4'-hydroxyphenoxy)pyrrolidin-2-one (1), and eight known steroids, (22E,24R)-7 beta,8 beta-epoxy-3 beta,5 alpha,9 alpha-trihydroxyergosta-22-en-6-one (2, a reassigned structure of (22E,24R)-5 alpha,6 alpha-epoxy-3 beta,8 beta,14 alpha-trihydroxyergosta-22-en-7-one), (22E,24R)-3 beta,5 alpha,9 alpha-trihydroxyergosta-7,22-dien-6-one (3), (22E,24R)-3 beta,5 alpha-dihydroxyergosta-7,22-dien-6-one (4), (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (5), (22E,24R)-ergosta-5,22-dien-3 beta-ol (6), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,22-dien-3 beta-ol (7), (22E,24R)-5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (8), and (22E,24R)-1(10 -> 6)-abeo-ergosta-5,7,9,22-tetraen-3 alpha-ol (9), were isolated from the cultures of Gibberella zeae, an endophytic fungus isolated from the marine green alga Codium fragile. Their structures and relative stereochemistry were elucidated by 1D, 2D NMR and mass spectroscopic techniques. Compound 1 showed cytotoxicity against A-549 and BEL-7402 cell lines.
文章类型	Article
资助机构	Chinese Academy of Sciences for Key Topics in Innovation Engineering[KZCX2-YW-QN209, KSCX2-EW-G-12B]; Shandong Province Natural Science Foundation[ZR2009BQ021]; Yantai Municipal Sci-Tech Development Program[2009164]; Foundation of the Chinese Academy of Sciences
收录类别	SCI
语种	英语
关键词[WOS]	FUSARIUM-ROSEUM ATCC-28114 ; MINOR METABOLITES ; FRUIT BODIES ; CONSTITUENTS ; GRAMINEARUM
研究领域[WOS]	Pharmacology & Pharmacy ; Food Science & Technology
WOS记录号	WOS:000294381500008
引用统计	被引频次：12[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/5113
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Shandong Agr Univ, Coll Food Sci & Engn, Tai An 271018, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,et al. A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain[J]. NATURAL PRODUCT COMMUNICATIONS,2011,6(9):1243-1246.
APA	Liu, Xiang-Hong,Tang, Xiao-Zhen,Miao, Feng-Ping,&Ji, Nai-Yun.(2011).A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain.NATURAL PRODUCT COMMUNICATIONS,6(9),1243-1246.
MLA	Liu, Xiang-Hong,et al."A New Pyrrolidine Derivative and Steroids from an Algicolous Gibberella zeae Strain".NATURAL PRODUCT COMMUNICATIONS 6.9(2011):1243-1246.

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