Quantum dots, lighting up the research and development of nanomedicine
Wang, Yunqing; Chen, Lingxin1
2011-08-01
发表期刊NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
ISSN1549-9634
卷号7期号:4页码:385-402
产权排序[Chen, LX] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai, Peoples R China
摘要Quantum dots (QDs) have proven themselves as powerful inorganic fluorescent probes, especially for long term, multiplexed imaging and detection. The newly developed QDs labeling techniques have facilitated the study of drug delivery on the level of living cells and small animals. Moreover, based on QDs and fluorescence imaging system, multifunctional nanocomplex integrated targeting, imaging and therapeutic functionalities have become effective materials for synchronous cancer diagnosis and treatment. In this review, we will summarize the recent advances of QDs in the research of drug delivery system from the following aspects: surface modification strategies of QDs for drug delivery, QDs as drug nanocarriers, QD-labeled drug nanocarriers, QD-based fluorescence resonance energy transfer (FRET) technique for drug release study as well as the development of multifunctional nanomedicines. Possible perspective in this field will also be discussed. From the Clinical Editor: This review discusses the role and significance of quantum dots (QDs) from the following aspects: surface modification strategies of QDs for drug delivery, QDs as drug nanocarriers, QD-labeled drug nanocarriers, QD-based fluorescence resonance energy transfer (FRET) technique for drug release study as well as the development of multifunctional nanomedicines. (C) 2011 Elsevier Inc. All rights reserved.; Quantum dots (QDs) have proven themselves as powerful inorganic fluorescent probes, especially for long term, multiplexed imaging and detection. The newly developed QDs labeling techniques have facilitated the study of drug delivery on the level of living cells and small animals. Moreover, based on QDs and fluorescence imaging system, multifunctional nanocomplex integrated targeting, imaging and therapeutic functionalities have become effective materials for synchronous cancer diagnosis and treatment. In this review, we will summarize the recent advances of QDs in the research of drug delivery system from the following aspects: surface modification strategies of QDs for drug delivery, QDs as drug nanocarriers, QD-labeled drug nanocarriers, QD-based fluorescence resonance energy transfer (FRET) technique for drug release study as well as the development of multifunctional nanomedicines. Possible perspective in this field will also be discussed.
通讯作者Chen, LX, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. lxchen@yic.ac.cn
关键词Quantum Dots Nanomedicine Fluorescence Imaging Multifunctional Drug Delivery System
作者部门环境化学实验室 
学科领域Science & Technology - Other Topics ; Research & Experimental Medicine
项目资助者National Natural Science Foundation of China[20975089]; Chinese Academy of Sciences[KZCX2-EW-206]; Department of Science and Technology of Shandong Province of China[2008GG20005005]
收录类别SCI
关键词[WOS]FREE POLY(LACTIDE-CO-GLYCOLIDE) NANOPARTICLES ; HYALURONIC-ACID DERIVATIVES ; RESONANCE ENERGY-TRANSFER ; GROWTH-FACTOR RECEPTOR ; TUMOR-CELL UPTAKE ; IN-VIVO ; DRUG-DELIVERY ; LIVING CELLS ; CARBON NANOTUBES ; SIRNA DELIVERY
文章类型Review
语种英语
WOS研究方向Science & Technology - Other Topics ; Research & Experimental Medicine
WOS记录号WOS:000293218800003
引用统计
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/5111
专题中科院海岸带环境过程与生态修复重点实验室_环境化学实验室
中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
3.Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai, Peoples R China
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Wang, Yunqing,Chen, Lingxin. Quantum dots, lighting up the research and development of nanomedicine[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2011,7(4):385-402.
APA Wang, Yunqing,&Chen, Lingxin.(2011).Quantum dots, lighting up the research and development of nanomedicine.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,7(4),385-402.
MLA Wang, Yunqing,et al."Quantum dots, lighting up the research and development of nanomedicine".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 7.4(2011):385-402.
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