Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells
Yu, Chunwei ; Chen, Lingxin ; Zhang, Jun ; Li, Jinhua ; Liu, Ping ; Wang, Wenhai ; Yan, Bing
2011
Source PublicationTALANTA
ISSN0039-9140
Volume85Issue:3Pages:1627-1633
Contribution Rank[Yu, CW; Chen, LX; Li, JH; Liu, P; Wang, WH] Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Yan, B] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China; [Zhang, J] Hainan Med Univ, Sch Trop & Lab Med, Haikou 571101, Peoples R China; [Yu, CW] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
AbstractA novel Cu(2+)-specific "off-on" fluorescent chemosensor of naphthalimide modified rhodamine B (naphthalimide modified rhodamine B chemosensor, NRC) was designed and synthesized, based on the equilibrium between the spirolactam (non-fluorescence) and the ring-opened amide (fluorescence). The chemosensor NRC showed high Cu(2+)-selective fluorescence enhancement over commonly coexistent metal ions or anions in neutral aqueous media. The limit of detection (LOD) based on 3 x delta(blank)/k was obtained as low as 0.18 mu M of Cu(2+), as well as an excellent linearity of 0.05-4.5 mu M (R=0.999), indicating the chemosensor of high sensitivity and wide quantitation range. And also the coordination mode with 1:1 stoichiometry was proposed between NRC and Cu(2+). In addition, the effects of pH, co-existing metal ions and anions, and the reversibility were investigated in detail. It was also demonstrated that the NRC could be used as an excellent "off-on" fluorescent chemosensor for the measurement of Cu(2+) in living cells with satisfying results, which further displayed its valuable applications in biological systems. (C) 2011 Elsevier B.V. All rights reserved.
Corresponding AuthorChen, LX, Chinese Acad Sci, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China. lxchen@yic.ac.cn ; dr.bingyan@gmail.com
KeywordCu(2+) Fluorescent Chemosensor Rhodamine b Fluorescence Imaging Living Cells
Department环境化学实验室 
Subject AreaChemistry
Funding OrganizationNational Natural Science Foundation of China[20975089, 90913006, 21077068]; Chinese Academy of Sciences[KZCX2-EW-206]; National Basic Research Program of China[2010CB933504]; Department of Science and Technology of Shandong Province[2008GG20005005]; Research and Training Foundation of Hainan Medical University[HY2010-004]
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/5105
Collection中科院海岸带环境过程与生态修复重点实验室_环境化学实验室
中科院海岸带环境过程与生态修复重点实验室
Recommended Citation
GB/T 7714
Yu, Chunwei,Chen, Lingxin,Zhang, Jun,et al. Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells[J]. TALANTA,2011,85(3):1627-1633.
APA Yu, Chunwei.,Chen, Lingxin.,Zhang, Jun.,Li, Jinhua.,Liu, Ping.,...&Yan, Bing.(2011).Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells.TALANTA,85(3),1627-1633.
MLA Yu, Chunwei,et al."Off-On based fluorescent chemosensor for Cu(2+) in aqueous media and living cells".TALANTA 85.3(2011):1627-1633.
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