| Recent advances in molecular imprinting technology: current status, challenges and highlighted applications | |
Chen, Lingxin1 ; Xu, Shoufang1,2; Li, Jinhua1
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| 2011 | |
| Source Publication | CHEMICAL SOCIETY REVIEWS
 |
| ISSN | 0306-0012 |
| Volume | 40Issue:5Pages:2922-2942 |
| Contribution Rank | [Chen, Lingxin; Xu, Shoufang; Li, Jinhua] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Xu, Shoufang] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Abstract | Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).; Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references). |
| Corresponding Author | Chen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China.lxchen@yic.ac.cn |
| Keyword | Solid-phase Extraction Performance Liquid-chromatography Restricted-access Materials Functionalized Silica-gel Beta-cyclodextrin Polymer Precipitation Polymerization Water Samples Ionic Liquid Selective Extraction Protein Recognition |
| Department | 环境化学实验室 |
| Subject Area | Chemistry, Multidisciplinary |
| Funding Organization | Chinese Academy of Sciences (IOCAS) [072715]; CAS/SAFEA |
| Indexed By | SCI |
| WOS Keyword | SOLID-PHASE EXTRACTION ; PERFORMANCE LIQUID-CHROMATOGRAPHY ; RESTRICTED-ACCESS MATERIALS ; FUNCTIONALIZED SILICA-GEL ; BETA-CYCLODEXTRIN POLYMER ; PRECIPITATION POLYMERIZATION ; WATER SAMPLES ; IONIC LIQUID ; SELECTIVE EXTRACTION ; PROTEIN RECOGNITION |
| Subtype | Review |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS ID | WOS:000289630700046 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/4853 |
| Collection | 中科院海岸带环境过程与生态修复重点实验室_环境化学实验室 中科院海岸带环境过程与生态修复重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Lingxin,Xu, Shoufang,Li, Jinhua. Recent advances in molecular imprinting technology: current status, challenges and highlighted applications[J]. CHEMICAL SOCIETY REVIEWS,2011,40(5):2922-2942. |
| APA | Chen, Lingxin,Xu, Shoufang,&Li, Jinhua.(2011).Recent advances in molecular imprinting technology: current status, challenges and highlighted applications.CHEMICAL SOCIETY REVIEWS,40(5),2922-2942. |
| MLA | Chen, Lingxin,et al."Recent advances in molecular imprinting technology: current status, challenges and highlighted applications".CHEMICAL SOCIETY REVIEWS 40.5(2011):2922-2942. |
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