Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering
Lou, Tingting1,2,5; Wang, Yunqing1,2; Li, Jinhua1,2; Peng, Hailong3,4; Xiong, Hua3; Chen, Lingxin1,2
2011-07-01
Source PublicationANALYTICAL AND BIOANALYTICAL CHEMISTRY
ISSN1618-2642
Volume401Issue:1Pages:333-338
Contribution Rank[Lou, Tingting; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China; [Lou, Tingting; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Peng, Hailong; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China; [Peng, Hailong] Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Peoples R China; [Lou, Tingting] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
AbstractA surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N = 3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices. .; A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N = 3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices.
Corresponding AuthorChen, LX, CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China.lxchen@yic.ac.cn
KeywordMelamine Surface-enhanced Raman Scattering Gold Nanoparticle 4-mercaptopyridine
Department环境化学实验室 
Subject AreaBiochemical Research Methods ; Chemistry, Analytical
Funding OrganizationNational Natural Science Foundation China [20807035, 50728806]; Chinese Academy of Sciences [KZCX2-YW-Q07-04]; Agency for Science, technology and Research (A*Star) of Singapore [R-288-000-066-305, 092 101 0059]
Indexed BySCI
WOS KeywordMASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; SILVER ELECTRODE ; INFANT FORMULA ; CYANURIC ACID ; SPECTROSCOPY ; MILK ; NANOCRYSTALS ; MOLECULES ; IDENTIFICATION
SubtypeArticle
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS IDWOS:000292156900031
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/4851
Collection中科院海岸带环境过程与生态修复重点实验室_环境化学实验室
中科院海岸带环境过程与生态修复重点实验室
Affiliation1.CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China
3.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China
4.Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Peoples R China
5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Lou, Tingting,Wang, Yunqing,Li, Jinhua,et al. Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2011,401(1):333-338.
APA Lou, Tingting,Wang, Yunqing,Li, Jinhua,Peng, Hailong,Xiong, Hua,&Chen, Lingxin.(2011).Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,401(1),333-338.
MLA Lou, Tingting,et al."Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 401.1(2011):333-338.
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