| Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering | |
Lou, Tingting1,2,5; Wang, Yunqing1,2 ; Li, Jinhua1,2; Peng, Hailong3,4; Xiong, Hua3; Chen, Lingxin1,2
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| 发表期刊 | ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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| ISSN | 1618-2642 |
| 2011-07-01 | |
| 卷号 | 401期号:1页码:333-338 |
| 关键词 | Melamine Surface-enhanced Raman Scattering Gold Nanoparticle 4-mercaptopyridine |
| 产权排序 | [Lou, Tingting; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China; [Lou, Tingting; Wang, Yunqing; Li, Jinhua; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Peng, Hailong; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China; [Peng, Hailong] Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Peoples R China; [Lou, Tingting] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 通讯作者 | Chen, LX, CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China.lxchen@yic.ac.cn |
| 作者部门 | 环境化学实验室 |
| 英文摘要 | A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N = 3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices. .; A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N = 3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation China [20807035, 50728806]; Chinese Academy of Sciences [KZCX2-YW-Q07-04]; Agency for Science, technology and Research (A*Star) of Singapore [R-288-000-066-305, 092 101 0059] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | MASS-SPECTROMETRY ; LIQUID-CHROMATOGRAPHY ; SILVER ELECTRODE ; INFANT FORMULA ; CYANURIC ACID ; SPECTROSCOPY ; MILK ; NANOCRYSTALS ; MOLECULES ; IDENTIFICATION |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| WOS记录号 | WOS:000292156900031 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/4851 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.CAS, Key Lab Coastal Zone Environm Proc, Beijing, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China 3.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China 4.Nanchang Univ, Dept Chem & Pharmaceut Engn, Nanchang 330031, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lou, Tingting,Wang, Yunqing,Li, Jinhua,et al. Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2011,401(1):333-338. |
| APA | Lou, Tingting,Wang, Yunqing,Li, Jinhua,Peng, Hailong,Xiong, Hua,&Chen, Lingxin.(2011).Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,401(1),333-338. |
| MLA | Lou, Tingting,et al."Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering".ANALYTICAL AND BIOANALYTICAL CHEMISTRY 401.1(2011):333-338. |
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