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Title:
Cancer-Targeting Multifunctionalized Gold Nanoparticles in Imaging and Therapy
Author: Jiao, P. F.2; Zhou, H. Y.1; Chen, L. X.3; Yan, B.1,4
Source: CURRENT MEDICINAL CHEMISTRY
ISSN: 0929-8673
Issued Date: 2011-05-01
Volume: 18, Issue:14, Pages:2086-2102
Keyword: Gold nanoparticles ; targeting moieties ; therapeutic payloads ; conjugation methods ; cancer imaging ; cancer therapy
Subject: Biochemistry & Molecular Biology; Chemistry ; Medicinal; Pharmacology & Pharmacy
Rank: [Zhou, H. Y.; Yan, B.] St Jude Childrens Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38105 USA; [Jiao, P. F.] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China; [Chen, L. X.] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China; [Yan, B.] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
Corresponding Author: Yan, B, Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China.Dr.bingyan@gmail.com
Department: 环境化学实验室 
Abstract: Nanotechnology has provided many promising nanoplatforms for targeted cancer imaging and therapy. Among these platforms, gold nanoparticles (GNPs) play a unique role in medicine because of their excellent physical and chemical properties. To expand the applications of GNPs in medicine, amounts of targeting moieties, imaging labels, and therapeutic agents have been integrated into these particles to form multifunctionalized GNPs. In this review, we highlight recent advances of the fabrication of cancer-targeting multifunctionalized GNPs and their applications in imaging and therapy.
English Abstract: Nanotechnology has provided many promising nanoplatforms for targeted cancer imaging and therapy. Among these platforms, gold nanoparticles (GNPs) play a unique role in medicine because of their excellent physical and chemical properties. To expand the applications of GNPs in medicine, amounts of targeting moieties, imaging labels, and therapeutic agents have been integrated into these particles to form multifunctionalized GNPs. In this review, we highlight recent advances of the fabrication of cancer-targeting multifunctionalized GNPs and their applications in imaging and therapy.
WOS Subject Extended: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS Keyword Plus: RECEPTOR-MEDIATED ENDOCYTOSIS ; GROWTH-FACTOR RECEPTOR ; DRUG-DELIVERY ; PHOTOTHERMAL ABLATION ; CONTRAST AGENTS ; IN-VITRO ; CONTROLLED-RELEASE ; OPTICAL-PROPERTIES ; RAMAN-SCATTERING ; FACILE SYNTHESIS
DOC Type: Review
Indexed Type: SCI
Language: 英语
WOS ID: WOS:000290612000005
Citation statistics:
Content Type: 期刊论文
URI: http://ir.yic.ac.cn/handle/133337/4838
Appears in Collections:环境化学实验室_期刊论文

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description.institution: 1.St Jude Childrens Res Hosp, Dept Chem Biol & Therapeut, Memphis, TN 38105 USA
2.Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Shandong, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
4.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

Recommended Citation:
Jiao, P. F.,Zhou, H. Y.,Chen, L. X.,et al. Cancer-Targeting Multifunctionalized Gold Nanoparticles in Imaging and Therapy[J]. CURRENT MEDICINAL CHEMISTRY,2011,18(14):2086-2102.
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