| Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs) | |
Zhou, Hailong1,2,3,4,5; Qu, Ying1,3,4; Wu, Huifeng1,3 ; Liao, Chunyang1,3; Zheng, Jiping2; Diao, Xiaoping2; Xue, Qinzhao1,3
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| 发表期刊 | CHEMOSPHERE
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| ISSN | 0045-6535 |
| 2010 | |
| 卷号 | 78期号:2页码:193-205 |
| 关键词 | Ahr Pathway Non-synonymous Nucleotide Substitutions (d(n)) Synonymous Nucleotide Substitutions (d(s)) Persistent Organic Pollutants (Pops) |
| 产权排序 | [Zhou, Hailong; Qu, Ying; Wu, Huifeng; Liao, Chunyang; Xue, Qinzhao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China; [Zhou, Hailong; Zheng, Jiping; Diao, Xiaoping] Hainan Univ, Coll Agr, Dept Biotechnol, Haikou 570228, Peoples R China; [Zhou, Hailong; Qu, Ying; Wu, Huifeng; Liao, Chunyang; Xue, Qinzhao] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China; [Zhou, Hailong; Qu, Ying] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Zhou, Hailong] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 通讯作者 | Xue, QZ, Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chunhui Rd, Yantai 264003, Shandong, Peoples R China |
| 作者部门 | 污染过程与控制实验室 |
| 英文摘要 | Phylogenetic analysis of AhR pathway genes and their evolutionary rate variations were studied on aquatic animals. The gene sequences for the proteins involved in this pathway were obtained from four major phylogenetic groups, including bivalvia, amphibian, teleostei and mammalia. These genes were distributed under four major steps of toxicology regulation: formation of cytosolic complex, translocation of AhR, heterodimerization of AhR and induction of CYP1A. The NJ, MP, and ML algorithm were used on protein coding DNA sequences to deduce the evolutionary relationship for the respective AhR pathway gene among different aquatic animals. The rate of non-synonymous nucleotide substitutions per non-synonymous site (d(N)) and synonymous nucleotide substitutions per synonymous site (d(S)) were calculated for different clade of the respective phylogenetic tree for each AhR pathway gene. The phylogenetic analysis suggests that evolutionary pattern of AhR pathway genes in aquatic animals is characterized mainly through gene duplication events or alterative splicing. The d(N) values indicate that all AhR pathway genes are well conserved in aquatic animals, except for CYP1A gene. Furthermore, compare with other aquatic animals, the d(N) value indicates that AhR pathway genes of fish are less conserved, and these genes likely go through an adaptive evolution within aquatic animals. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.; Phylogenetic analysis of AhR pathway genes and their evolutionary rate variations were studied on aquatic animals. The gene sequences for the proteins involved in this pathway were obtained from four major phylogenetic groups, including bivalvia, amphibian, teleostei and mammalia. These genes were distributed under four major steps of toxicology regulation: formation of cytosolic complex, translocation of AhR, heterodimerization of AhR and induction of CYP1A. The NJ, MP, and ML algorithm were used on protein coding DNA sequences to deduce the evolutionary relationship for the respective AhR pathway gene among different aquatic animals. The rate of non-synonymous nucleotide substitutions per non-synonymous site (d(N)) and synonymous nucleotide substitutions per synonymous site (d(S)) were calculated for different clade of the respective phylogenetic tree for each AhR pathway gene. The phylogenetic analysis suggests that evolutionary pattern of AhR pathway genes in aquatic animals is characterized mainly through gene duplication events or alterative splicing. The d(N) values indicate that all AhR pathway genes are well conserved in aquatic animals, except for CYP1A gene. Furthermore, compare with other aquatic animals, the d(N) value indicates that AhR pathway genes of fish are less conserved, and these genes likely go through an adaptive evolution within aquatic animals. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved. |
| 文章类型 | Review |
| 资助机构 | Chinese Academy of Sciences [KZCX2-YW-Q07-05]; Yantai Research and Development Program [2007323]; National Natural Science Foundation of China [20907039]; Natural Science Foundation of Hainan Province [309010] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | NUCLEAR TRANSLOCATOR ARNT ; KILLIFISH FUNDULUS-HETEROCLITUS ; ZEBRAFISH DANIO-RERIO ; FROG XENOPUS-LAEVIS ; SALMON SALMO-SALAR ; HEAT-SHOCK-PROTEIN ; DNA-BINDING ; DIOXIN RECEPTOR ; LIGAND-BINDING ; FUNCTIONAL-CHARACTERIZATION |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| WOS记录号 | WOS:000272888200017 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/3797 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 中国科学院烟台海岸带研究所知识产出 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 2.Hainan Univ, Coll Agr, Dept Biotechnol, Haikou 570228, Peoples R China 3.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China 4.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Hailong,Qu, Ying,Wu, Huifeng,et al. Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)[J]. CHEMOSPHERE,2010,78(2):193-205. |
| APA | Zhou, Hailong.,Qu, Ying.,Wu, Huifeng.,Liao, Chunyang.,Zheng, Jiping.,...&Xue, Qinzhao.(2010).Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs).CHEMOSPHERE,78(2),193-205. |
| MLA | Zhou, Hailong,et al."Molecular phylogenies and evolutionary behavior of AhR (aryl hydrocarbon receptor) pathway genes in aquatic animals: Implications for the toxicology mechanism of some persistent organic pollutants (POPs)".CHEMOSPHERE 78.2(2010):193-205. |
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