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题名:
Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo
作者: Wang, YunQing(王运庆)1,2,3; Ye, Chao1,2; Wu, Liheng1,2; Hu, Yuzhu1,2
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN号: 0731-7085
出版日期: 2010-11-02
卷号: 53, 期号:3, 页码:235-242
关键词: CdHgTe/gelatin nanospheres ; Biomimetic synthesis ; Fluorescent probes ; Near infrared imaging ; In vivo visible drug nanocarriers
学科分类: Chemistry, Analytical; Pharmacology & Pharmacy
产权排序: [Wang, Yunqing; Ye, Chao; Wu, Liheng; Hu, Yuzhu] Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China; [Wang, Yunqing; Ye, Chao; Wu, Liheng; Hu, Yuzhu] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China; [Wang, Yunqing] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
通讯作者: Hu, YZ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China
作者部门: 环境化学实验室 
中文摘要: This work presented a kind of novel near infrared emitting CdHgTe/gelatin nanospheres which were synthesized with Cd(NO3)(2), Hg(NO3)(2). NaHTe and a thiol stabilizer in gelatin solution The self-assembled nanospheres were megranate-like and nearly 40 nm in diameter, with CdHgTe QDs uniformly embedded in gelatin matrix. They exhibited strong fluorescence ranging from 580 to 800 nm that could be tuned by molar ratios of Hg2+ and gelatin. The full widths at half-maximum of the emission spectra were in the range of 60-80 nm. Compared with bare CdHgTe QDs, the photostability of this compact complex nanostructure remarkably improved. Moreover, the fluorescence of CdHgTe/gelatin nanospheres was much more resistant to the interference from certain kinds of endogenous biomolecules such as HSA, transferrin and hemoglobin Further applications of living cells and mouse imaging were demonstrated with an in vivo near infrared fluorescence imaging system The Inherent advantages of high stability as well as high fluorescence intensity make the nanospheres particular interested NIR bioprobe candidates for in vivo imaging studies (C) 2010 Elsevier B.V. All rights reserved
英文摘要: This work presented a kind of novel near infrared emitting CdHgTe/gelatin nanospheres which were synthesized with Cd(NO(3))(2), Hg(NO(3))(2). NaHTe and a thiol stabilizer in gelatin solution The self-assembled nanospheres were megranate-like and nearly 40 nm in diameter, with CdHgTe QDs uniformly embedded in gelatin matrix. They exhibited strong fluorescence ranging from 580 to 800 nm that could be tuned by molar ratios of Hg(2+) and gelatin. The full widths at half-maximum of the emission spectra were in the range of 60-80 nm. Compared with bare CdHgTe QDs, the photostability of this compact complex nanostructure remarkably improved. Moreover, the fluorescence of CdHgTe/gelatin nanospheres was much more resistant to the interference from certain kinds of endogenous biomolecules such as HSA, transferrin and hemoglobin Further applications of living cells and mouse imaging were demonstrated with an in vivo near infrared fluorescence imaging system The Inherent advantages of high stability as well as high fluorescence intensity make the nanospheres particular interested NIR bioprobe candidates for in vivo imaging studies (C) 2010 Elsevier B.V. All rights reserved
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: QUANTUM DOTS ; MOUSE MODEL ; NANOPARTICLES ; GROWTH
文章类型: Article
收录类别: SCI ; ISTP
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000280435800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/3732
Appears in Collections:环境化学实验室_期刊论文

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作者单位: 1.Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China
2.China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China

Recommended Citation:
Wang, Yunqing,Ye, Chao,Wu, Liheng,et al. Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2010,53(3):235-242.
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