Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo
Wang, Yunqing1,2,3; Ye, Chao1,2; Wu, Liheng1,2; Hu, Yuzhu1,2
2010-11-02
Source PublicationJOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ISSN0731-7085
Volume53Issue:3Pages:235-242
Contribution Rank[Wang, Yunqing; Ye, Chao; Wu, Liheng; Hu, Yuzhu] Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China; [Wang, Yunqing; Ye, Chao; Wu, Liheng; Hu, Yuzhu] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China; [Wang, Yunqing] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
AbstractThis work presented a kind of novel near infrared emitting CdHgTe/gelatin nanospheres which were synthesized with Cd(NO3)(2), Hg(NO3)(2). NaHTe and a thiol stabilizer in gelatin solution The self-assembled nanospheres were megranate-like and nearly 40 nm in diameter, with CdHgTe QDs uniformly embedded in gelatin matrix. They exhibited strong fluorescence ranging from 580 to 800 nm that could be tuned by molar ratios of Hg2+ and gelatin. The full widths at half-maximum of the emission spectra were in the range of 60-80 nm. Compared with bare CdHgTe QDs, the photostability of this compact complex nanostructure remarkably improved. Moreover, the fluorescence of CdHgTe/gelatin nanospheres was much more resistant to the interference from certain kinds of endogenous biomolecules such as HSA, transferrin and hemoglobin Further applications of living cells and mouse imaging were demonstrated with an in vivo near infrared fluorescence imaging system The Inherent advantages of high stability as well as high fluorescence intensity make the nanospheres particular interested NIR bioprobe candidates for in vivo imaging studies (C) 2010 Elsevier B.V. All rights reserved; This work presented a kind of novel near infrared emitting CdHgTe/gelatin nanospheres which were synthesized with Cd(NO(3))(2), Hg(NO(3))(2). NaHTe and a thiol stabilizer in gelatin solution The self-assembled nanospheres were megranate-like and nearly 40 nm in diameter, with CdHgTe QDs uniformly embedded in gelatin matrix. They exhibited strong fluorescence ranging from 580 to 800 nm that could be tuned by molar ratios of Hg(2+) and gelatin. The full widths at half-maximum of the emission spectra were in the range of 60-80 nm. Compared with bare CdHgTe QDs, the photostability of this compact complex nanostructure remarkably improved. Moreover, the fluorescence of CdHgTe/gelatin nanospheres was much more resistant to the interference from certain kinds of endogenous biomolecules such as HSA, transferrin and hemoglobin Further applications of living cells and mouse imaging were demonstrated with an in vivo near infrared fluorescence imaging system The Inherent advantages of high stability as well as high fluorescence intensity make the nanospheres particular interested NIR bioprobe candidates for in vivo imaging studies (C) 2010 Elsevier B.V. All rights reserved
Corresponding AuthorHu, YZ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China
KeywordCdhgte/gelatin Nanospheres Biomimetic Synthesis Fluorescent Probes Near Infrared Imaging In Vivo Visible Drug Nanocarriers
Department环境化学实验室 
Subject AreaChemistry, Analytical ; Pharmacology & Pharmacy
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Indexed BySCI ; ISTP
WOS KeywordQUANTUM DOTS ; MOUSE MODEL ; NANOPARTICLES ; GROWTH
SubtypeArticle
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS IDWOS:000280435800003
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/3731
Collection中科院海岸带环境过程与生态修复重点实验室_环境化学实验室
Affiliation1.Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China
2.China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
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Wang, Yunqing,Ye, Chao,Wu, Liheng,et al. Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2010,53(3):235-242.
APA Wang, Yunqing,Ye, Chao,Wu, Liheng,&Hu, Yuzhu.(2010).Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,53(3),235-242.
MLA Wang, Yunqing,et al."Synthesis and characterization of self-assembled CdHgTe/gelatin nanospheres as stable near infrared fluorescent probes in vivo".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 53.3(2010):235-242.
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