Advanced  
YIC-IR  > 环境化学实验室  > 期刊论文
Title:
Molecular fluorescent probes for monitoring pH changes in living cells
Author: Wang, Rui1; Yu, Chunwei1,2; Yu FaBiao(于法标)1; Chen, LingXin(陈令新)1
Source: TRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN: 0165-9936
Issued Date: 2010-10-01
Volume: 29, Issue:9, Pages:1004-1013
Keyword: Fluorescence microscopy ; Fluorescent probe ; Intracellular pH ; Living cell ; Organic synthesis ; pH detection ; pH indicator ; pH regulation ; Signal transduction ; Small molecular probe
Subject: Chemistry, Analytical
Rank: [Wang, Rui; Yu, Chunwei; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Yu, Chunwei] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Corresponding Author: Chen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
Department: 环境化学实验室 
Abstract: The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.
English Abstract: The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.
WOS Subject Extended: Chemistry
WOS Keyword Plus: AQUEOUS-SOLUTIONS ; INTRACELLULAR PH ; HEPG2 CELLS ; SENSORS ; ACIDIFICATION ; DERIVATIVES ; DYES ; CA2+ ; EXCITATION ; INHIBITION
DOC Type: Review
Indexed Type: SCI
Related URLs: 查看原文
Language: 英语
WOS ID: WOS:000282542800014
Citation statistics:
Content Type: 期刊论文
URI: http://ir.yic.ac.cn/handle/133337/3720
Appears in Collections:环境化学实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Molecular fluorescent probes for monitoring pH changes in living cells.pdf(268KB)----开放获取--View Download

description.institution: 1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Wang, Rui,Yu, Chunwei,Yu, Fabiao,et al. Molecular fluorescent probes for monitoring pH changes in living cells[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2010,29(9):1004-1013.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Rui]'s Articles
[Yu, Chunwei]'s Articles
[Yu, Fabiao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Rui]‘s Articles
[Yu, Chunwei]‘s Articles
[Yu, Fabiao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Molecular fluorescent probes for monitoring pH changes in living cells.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院烟台海岸带研究所 - Feedback
Powered by CSpace