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题名:
Molecular fluorescent probes for monitoring pH changes in living cells
作者: Wang, Rui1; Yu, Chunwei1,2; Yu FaBiao(于法标)1; Chen, LingXin(陈令新)1
刊名: TRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN号: 0165-9936
出版日期: 2010-10-01
卷号: 29, 期号:9, 页码:1004-1013
关键词: Fluorescence microscopy ; Fluorescent probe ; Intracellular pH ; Living cell ; Organic synthesis ; pH detection ; pH indicator ; pH regulation ; Signal transduction ; Small molecular probe
学科分类: Chemistry, Analytical
产权排序: [Wang, Rui; Yu, Chunwei; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Yu, Chunwei] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
通讯作者: Chen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
作者部门: 环境化学实验室 
中文摘要: The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.
英文摘要: The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.
研究领域[WOS]: Chemistry
关键词[WOS]: AQUEOUS-SOLUTIONS ; INTRACELLULAR PH ; HEPG2 CELLS ; SENSORS ; ACIDIFICATION ; DERIVATIVES ; DYES ; CA2+ ; EXCITATION ; INHIBITION
文章类型: Review
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000282542800014
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内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/3720
Appears in Collections:环境化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China

Recommended Citation:
Wang, Rui,Yu, Chunwei,Yu, Fabiao,et al. Molecular fluorescent probes for monitoring pH changes in living cells[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2010,29(9):1004-1013.
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