| Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons | |
Liao, Chun-yang1,2 ; Cui, Lin1; Zhou, Qun-fang1; Duan, Shu-min3,4; Jiang, Gui-bin1
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| 发表期刊 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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| ISSN | 1382-6689 |
| 2009-05-01 | |
| 卷号 | 27期号:3页码:338-344 |
| 关键词 | Perfluorooctane Sulfonate (Pfos) Neurotoxicity Potassium Channel Sodium Channel Glutamate-activated Current |
| 产权排序 | Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr; Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev;Chinese Acad Sci, Inst Neurosci;Chinese Acad Sci, State Key Lab Neurobiol, Shanghai Inst Biol Sci |
| 通讯作者 | Jiang, GB, Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr, POB 2871, Beijing 100085, Peoples R China |
| 作者部门 | 污染过程与控制实验室 |
| 英文摘要 | Concern on an emerging persistent contaminant, perfluorooctane sulfonate (PFOS), is increasingly growing. Although the fate, transport. distribution and bioaccumulation of PFOS have been documented, its toxicological effects especially neurotoxicity remain largely unknown. In this study, the effects of PFOS on ion channels including potassium and sodium channels and exogenous glutamate-activated current in cultured rat hippocampal neurons were examined, based on whole-cell patch-clamp recording. PFOS markedly increased two subtypes of potassium currents, including transient outward current and delayed rectifier current, at doses over 10 mu M. PFOS did not affect the amplitude of sodium current at all administrated doses (1, 10 or 100 mu M) but clearly shifted the activation current-voltage curve toward negatively potential. Further. PFOS significantly altered the glutamate-activated current at all doses. Taken together these findings indicated that PFOS disturbs the neuronal physiological processes, which revealed the damage of this pollutant to nerve system and will be helpful for further exploration to its underlying mechanism. (C) 2009 Published by Elsevier B.V. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China ; National Basic Research Program of China ; Chinese Academy of Sciences |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | VENTRICULAR MYOCYTES ; PERFLUORINATED COMPOUNDS ; PERFLUOROALKYL ACIDS ; PFOA CONCENTRATIONS ; MASS-SPECTROMETRY ; NHANES 1999-2000 ; NATIONAL-HEALTH ; US POPULATION ; K+ CURRENT ; INHIBITION |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| WOS记录号 | WOS:000265479000005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/3528 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Ecoenvironm Sci Res Ctr, Beijing 100085, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev, Yantai 264003, Shandong, Peoples R China 3.Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, State Key Lab Neurobiol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Chun-yang,Cui, Lin,Zhou, Qun-fang,et al. Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2009,27(3):338-344. |
| APA | Liao, Chun-yang,Cui, Lin,Zhou, Qun-fang,Duan, Shu-min,&Jiang, Gui-bin.(2009).Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,27(3),338-344. |
| MLA | Liao, Chun-yang,et al."Effects of perfluorooctane sulfonate on ion channels and glutamate-activated current in cultured rat hippocampal neurons".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 27.3(2009):338-344. |
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