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Title:
Growth-associated biosynthesis of astaxanthin in heterotrophic Chlorella zofingiensis (Chlorophyta)
Author: Wang, Yan(王艳)1,2; Peng, J.2
Source: WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
ISSN: 0959-3993
Issued Date: 2008-09-01
Volume: 24, Issue:9, Pages:1915-1922
Keyword: astaxanthin ; Chlorella zofingiensis ; glucose ; heterotrophic culture
Subject: Biotechnology & Applied Microbiology
Rank: Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev;Chinese Acad Sci, S China Sea Inst Oceanol
Corresponding Author: Wang, Y, Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev, Yantai 264003, Shandong, Peoples R China
Department: 生物资源实验室
English Abstract: The green microalga Chlorella zofingiensis can produce the ketocarotenoid astaxanthin under heterotrophic culture conditions. Here we report the growth-associated biosynthesis of astaxanthin in this biotechnologically important alga. With glucose as sole carbon and energy source, C. zofinginesis grew fast in the dark with rapid exhaustion of nitrogen and carbon sources from media, leading to a high specific growth rate (0.034 h(-1)). Cultures started at a cell concentration of about 3.4 x 10(9) cells l(-1) reached, after 6 days, standing biomass values of 1.6 x 10(11) cells or 8.5 g dry weight l(-1). Surprisingly, the biosynthesis of astaxanthin was found to start at early exponential phase, independent of cessation of cell division. A general trend was observed that the culture conditions benefiting cell growth also benefited astaxanthin accumulation, indicating that astaxanthin was a growth-associated product in this alga. The maximum cell dry biomass and astaxanthin yield were 11.75 g l(-1) and 11.14 mg l(-1) (about 1 mg g(-1)), simultaneously obtained in the fed-batch culture with a combined glucose-nitrate mixture addition, which were the highest ever reported in dark-heterotrophic algal cultures. The possible reasons why dark-heterotrophic C. zofingiensis could produce astaxanthin during the course of cell growth were discussed.
WOS Subject Extended: Biotechnology & Applied Microbiology
WOS Keyword Plus: HAEMATOCOCCUS-PLUVIALIS ; PHAFFIA-RHODOZYMA ; GREEN-ALGA ; CAROTENOID BIOSYNTHESIS ; SECONDARY CAROTENOIDS ; MIXOTROPHIC CULTURE ; CHLOROCOCCUM SP ; ACCUMULATION ; MICROALGAE ; STRESS
DOC Type: Article
Indexed Type: SCI
Related URLs: 查看原文
Language: 英语
WOS ID: WOS:000257961500036
Citation statistics:
Content Type: 期刊论文
URI: http://ir.yic.ac.cn/handle/133337/3500
Appears in Collections:海岸带生物学与生物资源利用所重点实验室_期刊论文

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description.institution: 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res Sustainable Dev, Yantai 264003, Shandong, Peoples R China
2.Chinese Acad Sci, S China Sea Inst Oceanol, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Wang, Y.,Peng, J.. Growth-associated biosynthesis of astaxanthin in heterotrophic Chlorella zofingiensis (Chlorophyta)[J]. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY,2008,24(9):1915-1922.
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