The Antioxidant and Antibacterial Activities of the Pyridine-4-Aldehyde Schiff Bases Grafted Chloracetyl Chitosan Oligosaccharide Derivatives

doi:10.1002/star.202100268

	The Antioxidant and Antibacterial Activities of the Pyridine-4-Aldehyde Schiff Bases Grafted Chloracetyl Chitosan Oligosaccharide Derivatives
	Zhang, Jingjing 1; Zhang, Shijin 2; Wang, Linqing 3; Tan, Wenqiang1 ; Li, Qing1 ; Guo, Zhanyong1,4
发表期刊	STARCH-STARKE
ISSN	0038-9056
	2022-11-03
页码	11
关键词	antibacterial activity antioxidant activity Schiff bases grafted chitosan oligosaccharide derivatives
DOI	10.1002/star.202100268
通讯作者	Guo, Zhanyong(zyguo@yic.ac.cn)
英文摘要	As a reactive intermediate, chloracetyl chitosan oligosaccharide (CACS) can be nucleophilic substituted by some bioactive groups to give novel derivatives of chitosan oligosaccharide (COS). The Schiff bases of pyridine-4-aldehyde are grafted onto CACS to give four COS derivatives in this paper. Specific structural characterization is implemented by fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR). The degree of substitution (DS) of COS derivatives is quantitatively calculated by ratio of hydrogen proton integral. Their antioxidant property is evaluated using free radical scavenging assay towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion radicals, and the antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) is also investigated. The results revealed that the pyridine-4-aldehyde Schiff bases grafted chloracetyl chitosan oligosaccharide derivatives showed better antioxidant activity as well as antibacterial activity than COS and CACS, which may be related to the positive charge of these derivatives. Among all final products, derivative BPCACS with the highest DS has the best bioactivity with scavenging rate of 91.49% for the DPPH assay and inhibition diameter of 39.25 mm for S. aureus inhibitory assay, respectively. These results indicated that COS derivatives with enhanced biological activities could serve as potential biomaterial for antioxidant and antibacterial applications.
资助机构	National Key Research and Development Program of China ; Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province of China ; Chinese Academy of Sciences
收录类别	SCI
语种	英语
关键词[WOS]	INULIN DERIVATIVES ; NANOCOMPOSITE
研究领域[WOS]	Food Science & Technology
WOS记录号	WOS:000878330900001
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/32021
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Harbin Inst Technol Weihai, Weihai 264209, Peoples R China 3.Ludong Univ, Yantai 264025, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jingjing,Zhang, Shijin,Wang, Linqing,et al. The Antioxidant and Antibacterial Activities of the Pyridine-4-Aldehyde Schiff Bases Grafted Chloracetyl Chitosan Oligosaccharide Derivatives[J]. STARCH-STARKE,2022:11.
APA	Zhang, Jingjing,Zhang, Shijin,Wang, Linqing,Tan, Wenqiang,Li, Qing,&Guo, Zhanyong.(2022).The Antioxidant and Antibacterial Activities of the Pyridine-4-Aldehyde Schiff Bases Grafted Chloracetyl Chitosan Oligosaccharide Derivatives.STARCH-STARKE,11.
MLA	Zhang, Jingjing,et al."The Antioxidant and Antibacterial Activities of the Pyridine-4-Aldehyde Schiff Bases Grafted Chloracetyl Chitosan Oligosaccharide Derivatives".STARCH-STARKE (2022):11.