Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties
Cui, Jingmin1,2,3; Sun, Yan1,2,3; Wang, Linqing4; Miao, Qin1,2,3; Tan, Wenqiang1,3; Guo, Zhanyong1,2,3
发表期刊MARINE DRUGS
2022-11-01
卷号20期号:11页码:16
关键词chitosan l-arginine Schiff bases heterocyclic compounds
DOI10.3390/md20110688
英文摘要We successfully prepared a series of l-arginine Schiff bases acylated chitosan derivatives, aiming to improve the antioxidant activity and antimicrobial activity of chitosan by introducing a furan ring, pyridine ring, and l-arginine structure. The accuracy of the structures of ten compounds was characterized by FT-IR and H-1 NMR. In terms of DPPH radical scavenging activity, except for compound CR3PCA, the scavenging rate of other compounds was higher than chitosan, especially CRCF and CRBF had strong scavenging abilities. At the same time, in the superoxide-radical scavenging activity assay, CRCF, CRBF, CR3PCA, CR2C3PCA, and CR2B3PCA were comparable to positive control at 1.60 mg/mL. Simultaneously, CRFF, CRCF, and CRBF had a certain inhibitory effect on Botrytis cinerea. Furthermore, the inhibitory effect of CRFF, CRCF, and CR3PCA on Staphylococcus aureus was very well, close to the positive control at 1.00 mg/mL. CRCF and CR2B3PCA showed better inhibitory effects on Escherichia coli than other compounds. The MTT assay was used to determine the cytotoxicity of the chitosan derivatives, which proved their safety to fibroblast cells. In summary, the study indicated that some of these compounds have the potential for further development and utilization in the preparation of antioxidants and antimicrobial agents.
收录类别SCI
语种英语
关键词[WOS]AMINO-ACIDS ; ANTIBACTERIAL ; COMPLEXES ; MODE ; COPPER(II) ; PLANT
研究领域[WOS]Pharmacology & Pharmacy
WOS记录号WOS:000895550000001
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/31889
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者Guo, Zhanyong
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Oceanmega Sci, Qingdao 266071, Peoples R China
4.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China
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GB/T 7714
Cui, Jingmin,Sun, Yan,Wang, Linqing,et al. Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties[J]. MARINE DRUGS,2022,20(11):16.
APA Cui, Jingmin,Sun, Yan,Wang, Linqing,Miao, Qin,Tan, Wenqiang,&Guo, Zhanyong.(2022).Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties.MARINE DRUGS,20(11),16.
MLA Cui, Jingmin,et al."Preparation of l-Arginine Schiff Bases Modified Chitosan Derivatives and Their Antimicrobial and Antioxidant Properties".MARINE DRUGS 20.11(2022):16.
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