Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination | |
Arabi, Maryam1; Ostovan, Abbas1; Wang, Yunqing1,2 ; Mei, Rongchao1; Fu, Longwen1; Li, Jinhua1; Wang, Xiaoyan1,3; Chen, Lingxin1,2,4
| |
| Source Publication | NATURE COMMUNICATIONS
 |
| 2022-09-30 | |
| Volume | 13Issue:1Pages:14 |
| DOI | 10.1038/s41467-022-33448-w |
| Corresponding Author | Wang, Yunqing(yqwang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) |
| Abstract | Chiral discrimination is critical in environmental and life sciences. However, an ideal chiral discrimination strategy has not yet been developed because of the inevitable nonspecific binding entity of wrong enantiomers or insufficient intrinsic optical activities of chiral molecules. Here, we propose an "inspector" recognition mechanism (IRM), which is implemented on a chiral imprinted polydopamine (PDA) layer coated on surface-enhanced Raman scattering (SERS) tag layer. The IRM works based on the permeability change of the imprinted PDA after the chiral recognition and scrutiny of the permeability by an inspector molecule. Good enantiomer can specifically recognize and fully fill the chiral imprinted cavities, whereas the wrong cannot. Then a linear shape aminothiol molecule, as an inspector of the recognition status is introduced, which can only percolate through the vacant and nonspecifically occupied cavities, inducing the SERS signal to decrease. Accordingly, chirality information exclusively stems from good enantiomer specific binding, while nonspecific recognition of wrong enantiomer is curbed. The IRM benefits from sensitivity and versatility, enabling absolute discrimination of a wide variety of chiral molecules regardless of size, functional groups, polarities, optical activities, Raman scattering, and the number of chiral centers. |
| Funding Organization | Chinese Academy of Sciences President's International Fellowship Initiative ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Instrument Developing Project of the Chinese Academy of Sciences ; Technical Innovation Project of Instrument Function Development of the Chinese Academy of Sciences ; Taishan Scholar Project |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | POLYMERS ; PERSPECTIVES |
| WOS Research Area | Science & Technology - Other Topics |
| WOS ID | WOS:000862415000025 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/31752 |
| Collection | 中科院海岸带环境过程与生态修复重点实验室 中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 |
| Corresponding Author | Wang, Yunqing; Chen, Lingxin |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China |
| Recommended Citation GB/T 7714 | Arabi, Maryam,Ostovan, Abbas,Wang, Yunqing,et al. Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination[J]. NATURE COMMUNICATIONS,2022,13(1):14. |
| APA | Arabi, Maryam.,Ostovan, Abbas.,Wang, Yunqing.,Mei, Rongchao.,Fu, Longwen.,...&Chen, Lingxin.(2022).Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination.NATURE COMMUNICATIONS,13(1),14. |
| MLA | Arabi, Maryam,et al."Chiral molecular imprinting-based SERS detection strategy for absolute enantiomeric discrimination".NATURE COMMUNICATIONS 13.1(2022):14. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment