| Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp | |
Zhu, Xiaopeng1,2,3; Teng, Jia1,2,3; Xu, Elvis Genbo4; Zhao, Jianmin1,2 ; Shan, Encui1,2,3; Sun, Chaofan1,2,3; Wang, Qing1,2
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| Source Publication | ENVIRONMENTAL POLLUTION
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| ISSN | 0269-7491 |
| 2022-11-01 | |
| Volume | 312Pages:12 |
| Keyword | Nanoplastics Titanium dioxide nanoparticle Litopenaeus vannamei Bioaccumulation Toxic effect Intestinal microbiota |
| DOI | 10.1016/j.envpol.2022.120069 |
| Corresponding Author | Wang, Qing(qingwang@yic.ac.cn) |
| Abstract | Nanoplastic is recognized as an emerging environmental pollutant due to the anticipated ubiquitous distribution, increasing concentration in the ocean, and potential adverse health effects. While our understanding of the ecological impacts of nanoplastics is still limited, we benefit from relatively rich toxicological studies on other nanoparticles such as nano metal oxides. However, the similarity and difference in the toxicokinetic and tox-icodynamic aspects of plastic and metallic nanoparticles remain largely unknown. In this study, juvenile Pacific white shrimp Litopenaeus vannamei was exposed to two types of nanoparticles at environmentally relative low and high concentrations, i.e., 100 nm polystyrene nanoplastics (nano-PS) and titanium dioxide nanoparticles (nano-TiO2) via dietary exposure for 28 days. The systematic toxicological evaluation aimed to quantitatively compare the accumulation, excretion, and toxic effects of nano-PS and nano-TiO2. Our results demonstrated that both nanoparticles were ingested by L. vannamei with lower egestion of nano-TiO2 than nano-PS. Both nano -particles inhibited the growth of shrimps, damaged tissue structures of the intestine and hepatopancreas, dis-rupted expression of immune-related genes, and induced intestinal microbiota dysbiosis. Nano-PS exposure caused proliferative cells in the intestinal tissue, and the disturbance to the intestinal microbes was also more serious than that of nano-TiO2. The results indicated that the effect of nano-PS on the intestinal tissue of L. vannamei was more severe than that of nano-TiO2 with the same particle size. The study provides new theoretical basis of the similarity and differences of their toxicity, and highlights the current lack of knowledge on various aspects of absorption, distribution, metabolism, and excretion (ADME) pathways of nanoplastics. |
| Funding Organization | Strategic Priority Research Program of the Chinese Academy of Sciences ; National Key Research and Development Project ; National Natural Science Fund of China ; Two-Hundred Talents Plan of Yantai |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | GLUCAN BINDING-PROTEIN ; NANO-TITANIUM-DIOXIDE ; POLYSTYRENE MICROPLASTICS ; OXIDATIVE STRESS ; TIO2 NANOPARTICLES ; DAPHNIA-MAGNA ; TOXICITY ; MICROBIOTA ; ACCUMULATION ; NANOPLASTICS |
| WOS Research Area | Environmental Sciences & Ecology |
| WOS ID | WOS:000860790500001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/31743 |
| Collection | 海岸带生物学与生物资源利用重点实验室 支撑部门_中国科学院牟平海岸带环境综合试验站 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| Corresponding Author | Wang, Qing |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Southern Denmark, Dept Biol, DK-5230 Odense, Denmark |
| Recommended Citation GB/T 7714 | Zhu, Xiaopeng,Teng, Jia,Xu, Elvis Genbo,et al. Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp[J]. ENVIRONMENTAL POLLUTION,2022,312:12. |
| APA | Zhu, Xiaopeng.,Teng, Jia.,Xu, Elvis Genbo.,Zhao, Jianmin.,Shan, Encui.,...&Wang, Qing.(2022).Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp.ENVIRONMENTAL POLLUTION,312,12. |
| MLA | Zhu, Xiaopeng,et al."Toxicokinetics and toxicodynamics of plastic and metallic nanoparticles: A comparative study in shrimp".ENVIRONMENTAL POLLUTION 312(2022):12. |
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