Phycocyanin: Anti-inflammatory effect and mechanism
Liu, Runze1; Qin, Song1,2; Li, Wenjun1,2
发表期刊BIOMEDICINE & PHARMACOTHERAPY
ISSN0753-3322
2022-09-01
卷号153页码:10
关键词Phycocyanin Phycocyanobilin Inflammation Signal pathway Heme oxygenase 1 Kelch-like ECH-associated protein 1
DOI10.1016/j.biopha.2022.113362
通讯作者Li, Wenjun(wjli@yic.ac.cn)
英文摘要As the host defense response to various injuries and pathogens in the body, inflammation can remove damaged cells and pathogens in the host organism and protect the body. However, excessive inflammation may cause damage to normal tissue cells while removing pathogens, which in turn cause numerous inflammatory diseases and adversely affect the human health. Phycocyanin is an active substance extracted from algae; it has outstanding antioxidant and anti-inflammatory activities, and can effectively inhibit various diseases caused by inflammation. This review systematically summarizes recent applications of phycocyanin against various inflammatory diseases in lung, liver, cardiovascular, and cerebrovascular systems. In addition, possible antiinflammatory action pathways of phycocyanin are reviewed to canvass the anti-inflammatory mechanism. At last, based on the existing research, phycocyanobilin in phycocyanin is proposed as a bilirubin analog by inducing heme oxygenase 1 in vivo to suppress inflammation.
资助机构National Key Research and Development Program of China
收录类别SCI
语种英语
关键词[WOS]C-PHYCOCYANIN ; HEME OXYGENASE-1 ; SPIRULINA-PLATENSIS ; REDUCES INFLAMMATION ; BILIRUBIN ; ACTIVATION ; IMMUNE ; INJURY ; EXPRESSION ; APOPTOSIS
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS记录号WOS:000850076300002
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/31683
专题海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者Li, Wenjun
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
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Liu, Runze,Qin, Song,Li, Wenjun. Phycocyanin: Anti-inflammatory effect and mechanism[J]. BIOMEDICINE & PHARMACOTHERAPY,2022,153:10.
APA Liu, Runze,Qin, Song,&Li, Wenjun.(2022).Phycocyanin: Anti-inflammatory effect and mechanism.BIOMEDICINE & PHARMACOTHERAPY,153,10.
MLA Liu, Runze,et al."Phycocyanin: Anti-inflammatory effect and mechanism".BIOMEDICINE & PHARMACOTHERAPY 153(2022):10.
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