Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice

doi:10.1016/j.chemosphere.2022.133810

	Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice
	Liu, Jin 1,2; Lv, Min2 ; Sun, Anqi 3; Ding, Jing 1; Wang, Yunqing2 ; Chang, Xianbo 1; Chen, Lingxin2
发表期刊	CHEMOSPHERE
ISSN	0045-6535
	2022-05-01
卷号	294 页码:7
关键词	Microplastics Antibiotic Bioaccumulation Antibiotic resistance genes Synergistic effect
DOI	10.1016/j.chemosphere.2022.133810
通讯作者	Lv, Min(mlv@yic.ac.cn) ; Chang, Xianbo(cxb780806@126.com) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Microplastics (MPs) have aroused a global health concern and their coexistence with antibiotics is inevitable. However, how MPs would affect the bioaccumulation and risks of antibiotics in humans remains poorly understood. Here a mouse model was used, and through dietary exposure, we observed that while the relative distributions of sulfamethoxazole (SMX) in tissues were relatively stable, MPs significantly reduced the bioaccumulation of SMX in mice tissues (liver, lung, spleen, heart and kidney). Notably, while SMX and MPs showed a differential effect, MPs could exacerbate the effects of SMX on gut microbiota and antibiotic resistance gene (ARG) profile, with the relative abundances of sulfonamide resistance genes and multidrug genes being significantly increased. We further identified that shifts in gut microbiota contributed to the changes in ARG profiles in mice. Combined, our results demonstrate that MPs reduced the bioaccumulation of SMX, but they enhanced its effects on gut microbiota and the antibiotic resistome of mice, indicating they might have high risks to humans.
资助机构	Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; Plan Project of Shandong Science and Technology Development ; Taishan Scholar Project Special Funding
收录类别	SCI
语种	英语
关键词[WOS]	MYTILUS-EDULIS L. ; RESISTANCE GENES ; POLYETHYLENE ; NANOPLASTICS ; PHARMACEUTICALS ; TOXICITY ; BACTERIA ; SORPTION ; SEA
研究领域[WOS]	Environmental Sciences & Ecology
WOS记录号	WOS:000758333200006
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31514
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Lv, Min; Chang, Xianbo; Chen, Lingxin
作者单位	1.Yantai Univ, Sch Environm & Mat Engn, 30 Qingquan Rd, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, 17 Chunhui Rd, Yantai 264003, Peoples R China 3.Fujian Normal Univ, Sch Geog Sci, Key Lab Humid Subtrop Ecogeog Proc, Minist Educ, 8 Shangsan Rd, Fuzhou 350007, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jin,Lv, Min,Sun, Anqi,et al. Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice[J]. CHEMOSPHERE,2022,294:7.
APA	Liu, Jin.,Lv, Min.,Sun, Anqi.,Ding, Jing.,Wang, Yunqing.,...&Chen, Lingxin.(2022).Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice.CHEMOSPHERE,294,7.
MLA	Liu, Jin,et al."Exposure to microplastics reduces the bioaccumulation of sulfamethoxazole but enhances its effects on gut microbiota and the antibiotic resistome of mice".CHEMOSPHERE 294(2022):7.