Hormetic dose responses induced by organic flame retardants in aquatic animals: Occurrence and quantification

doi:10.1016/j.scitotenv.2022.153295

	Hormetic dose responses induced by organic flame retardants in aquatic animals: Occurrence and quantification
	Sun, Tao 1,3; Ji, Chenglong1,2,4 ; Li, Fei1,4 ; Wu, Huifeng1,2,4
发表期刊	SCIENCE OF THE TOTAL ENVIRONMENT
ISSN	0048-9697
	2022-05-10
卷号	820 页码:10
关键词	Organic flame retardants Hormesis Dose response Stress biology Aquatic environment
DOI	10.1016/j.scitotenv.2022.153295
通讯作者	Wu, Huifeng(hfwu@yic.ac.cn)
英文摘要	The organic flame retardants (OFRs) have attracted global concerns due to their potential toxicity and ubiquitous presence in the aquatic environment. Hormesis refers to a biphasic dose response, characterized by low-dose stimulation and high-dose inhibition. The present study provided substantial evidence for the widespread occurrence of OFRsinduced hormesis in aquatic animals, including 202 hormetic dose response relationships. The maximum stimulatory response (MAX) was commonly lower than 160% of the control response, with a combined value of 134%. Furthermore, the magnitude of MAX varied significantly among multiple factors and their interactions, such as chemical types and taxonomic groups. Moreover, the distance from the dose of MAX to the no-observed-adverse-effect-level (NOAEL) (NOAEL: MAX) was typically below 10-fold (median = 6-fold), while the width of the hormetic zone (from the lowest dose inducing hormesis to the NOAEL) was approximately 20-fold. Collectively, the quantitative features of OFRs-induced hormesis in aquatic animals were in accordance with the broader hormetic literature. In addition, the implications of hormetic dose response model for the risk assessment of OFRs were discussed. This study offered a novel insight for understanding the biological effects of low-to-high doses of OFRs on aquatic animals and assessing the potential risks of OFRs in the aquatic environment.
收录类别	SCI
语种	英语
关键词[WOS]	TRIS(1,3-DICHLORO-2-PROPYL) PHOSPHATE TDCPP ; DECABROMODIPHENYL ETHER BDE-209 ; POLYBROMINATED DIPHENYL ETHERS ; OXIDATIVE STRESS ; DEVELOPMENTAL TOXICITY ; DECHLORANE PLUS ; DAPHNIA-MAGNA ; IN-VIVO ; TOXICOLOGICAL RESPONSES ; THYROID-HORMONES
研究领域[WOS]	Environmental Sciences & Ecology
WOS记录号	WOS:000775486000012
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31280
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Wu, Huifeng
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Sun, Tao,Ji, Chenglong,Li, Fei,et al. Hormetic dose responses induced by organic flame retardants in aquatic animals: Occurrence and quantification[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2022,820:10.
APA	Sun, Tao,Ji, Chenglong,Li, Fei,&Wu, Huifeng.(2022).Hormetic dose responses induced by organic flame retardants in aquatic animals: Occurrence and quantification.SCIENCE OF THE TOTAL ENVIRONMENT,820,10.
MLA	Sun, Tao,et al."Hormetic dose responses induced by organic flame retardants in aquatic animals: Occurrence and quantification".SCIENCE OF THE TOTAL ENVIRONMENT 820(2022):10.