| Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice | |
Zhang, Yubing1,2; Qin, Song1,3 ; Song, Yipeng4; Yuan, Jingyi1,3; Hu, Shanliang4; Chen, Min2; Li, Lili1,3
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| Source Publication | FRONTIERS IN IMMUNOLOGY
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| ISSN | 1664-3224 |
| 2022-04-01 | |
| Volume | 13Pages:12 |
| Keyword | alginate oligosaccharide cisplatin gut microbiota metabolomics FAHFAs Nrf2 oxidative stress inflammation |
| DOI | 10.3389/fimmu.2022.857242 |
| Corresponding Author | Li, Lili(llli@yic.ac.cn) |
| Abstract | Alginate oligosaccharide is the depolymerized product of alginate, a natural extract of brown algae, which is associated with beneficial health effects. Here, we aimed to investigate the mechanism via which alginate oligosaccharides improve kidney oxidative damage and liver inflammation induced by cisplatin chemotherapy via the gut microbiota. C57BL/6J mice were treated with cisplatin were administered alginate oligosaccharide via gavage for 3 weeks. Compared to that observed in the cisplatin chemotherapy group without intragastric administration of alginate oligosaccharide, liver inflammation improved in the alginate oligosaccharide group, indicated by reduction in lipopolysaccharide and interleukin-1 beta (IL-1 beta) levels. This was accompanied by improvement in the oxidative stress of mice kidneys, indicated by the increase in the levels of superoxide dismutase (SOD), catalase (CAT) and nuclear NF-E2-related factor 2 (Nrf2) in renal tissue, and reduction in the levels of malondialdehyde (MDA) in renal tissue and serum creatinine (Cr) to the levels of the normal control group. Alginate oligosaccharide intervention increased the concentration of fatty acid esters of hydroxy fatty acids (FAHFAs). Alginate oligosaccharide regulated the composition of the intestinal microbial community and promoted Lactobacillus stains, such as Lactobacillus johnsonii and Lactobacillus reuteri. Spearman analysis showed that 5 members of FAHFAs concentrations were positively correlated with Lactobacillus johnsonii and Lactobacillus reuteri abundance. We observed that alginate oligosaccharide increased FAHFAs producing-related bacterial abundance and FAHFAs levels, enhanced the levels of SOD and CAT in kidney tissue, and reduced the levels of MDA via activating Nrf2, thereby ameliorating the renal redox injury caused by cisplatin chemotherapy. |
| Funding Organization | Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Program of Yantai |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | MICROBIOTA ; INJURY ; RESCUE |
| WOS Research Area | Immunology |
| WOS ID | WOS:000787926600001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/31250 |
| Collection | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| Corresponding Author | Li, Lili |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China 2.Yantai Univ, Coll Life Sci, Yantai, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China 4.Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Yubing,Qin, Song,Song, Yipeng,et al. Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice[J]. FRONTIERS IN IMMUNOLOGY,2022,13:12. |
| APA | Zhang, Yubing.,Qin, Song.,Song, Yipeng.,Yuan, Jingyi.,Hu, Shanliang.,...&Li, Lili.(2022).Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice.FRONTIERS IN IMMUNOLOGY,13,12. |
| MLA | Zhang, Yubing,et al."Alginate Oligosaccharide Alleviated Cisplatin-Induced Kidney Oxidative Stress via Lactobacillus Genus-FAHFAs-Nrf2 Axis in Mice".FRONTIERS IN IMMUNOLOGY 13(2022):12. |
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