Synthesis and characterization of alpha-lipoic acid grafted chitosan derivatives with antioxidant activity

doi:10.1016/j.reactfunctpolym.2022.105205

	Synthesis and characterization of alpha-lipoic acid grafted chitosan derivatives with antioxidant activity
	Tan, Wenqiang1,2 ; Zhang, Jingjing 1,2; Mi, Yingqi 1,2,3; Li, Qing1,2 ; Guo, Zhanyong1,2,3
发表期刊	REACTIVE & FUNCTIONAL POLYMERS
ISSN	1381-5148
	2022-03-01
卷号	172 页码:10
关键词	Chitosan derivative Chitosan acetate alpha-Lipoic acid Graft modification Antioxidant activity
DOI	10.1016/j.reactfunctpolym.2022.105205
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	Here, alpha-lipoic acid (LA) was grafted onto chitosan via EDC/NHS to improve the antioxidant effect. Chitosan acetate was innovatively used as precursor replaced pristine chitosan to synthesize alpha-lipoic acid grafted chitosan derivatives with different grafting ratios. The grafting ratio of LA-g-CS conjugates could be controlled by adjusting the reaction temperature, reaction time, and feed ratio of alpha-lipoic acid to anhydroglucose unit, and the feed ratio is the main factor on the grafting efficiency. The antioxidant results (superoxide anion, hydroxyl, and DPPH radicals scavenging activities, and reducing power) indicated that LA-g-CS displayed significantly enhanced antioxidant activity over pristine chitosan. Moreover, antioxidant efficiency of LA-g-CS showed an ascending tendency with the increasing of the grafting degree. The present study provided a novel synthesis strategy for preparation of alpha-lipoic acid grafted chitosan derivatives that could be a potential antioxidant biomaterial in food and biomedical industries.
资助机构	Natural Science Foun-dation of Shandong Province of China ; Youth Innova-tion Promotion Association CAS ; National Key Research and Development Program of China
收录类别	SCI
语种	英语
关键词[WOS]	SOLUBILITY ; MOTILITY ; RELEASE
研究领域[WOS]	Chemistry ; Engineering ; Polymer Science
WOS记录号	WOS:000786666300007
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31247
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,et al. Synthesis and characterization of alpha-lipoic acid grafted chitosan derivatives with antioxidant activity[J]. REACTIVE & FUNCTIONAL POLYMERS,2022,172:10.
APA	Tan, Wenqiang,Zhang, Jingjing,Mi, Yingqi,Li, Qing,&Guo, Zhanyong.(2022).Synthesis and characterization of alpha-lipoic acid grafted chitosan derivatives with antioxidant activity.REACTIVE & FUNCTIONAL POLYMERS,172,10.
MLA	Tan, Wenqiang,et al."Synthesis and characterization of alpha-lipoic acid grafted chitosan derivatives with antioxidant activity".REACTIVE & FUNCTIONAL POLYMERS 172(2022):10.