A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection

doi:10.1016/j.snb.2022.131830

	A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection
	Fu, Xiuli 1; Lin, Hao 1; Qi, Ji 3; Li, Fengling 1; Chen, Yan 2; Li, Bowei3 ; Chen, Lingxin3
发表期刊	SENSORS AND ACTUATORS B-CHEMICAL
	2022-07-01
卷号	362 页码:7
关键词	Paper-based platform Tetrahedral DNA nanostructure Colorimetric Mercury
DOI	10.1016/j.snb.2022.131830
通讯作者	Chen, Yan(ychen0612@163.com) ; Li, Bowei(bwli@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	A novel tetrahedral DNA nanostructure (TDN) functionalized paper-based colorimetric sensor was developed for ultrasensitive analysis of mercury ion (Hg2+). On the paper-based platform, TDN was used as scaffold to anchor aptamer to improve the capture efficiency owing to the controllably specific orientation, low steric hindrance effect and well-defined spacing. In the absence of Hg2+, biotinylated aptamer would bind with streptavidinlabeled HRP. Whereas, in the presence of Hg2+, aptamer would preferentially bind to Hg2+ owing to the higher binding constant of T-Hg-T than that of T-A, which consequently leading to the biotinylated aptamer releasing from TDN. After introducing TMB-H2O2 solution, strong variation of color signal could be observed. Therefore, the quantitative analysis of Hg2+ was carried out by using smartphone to monitor the color intensity on paper chip. The proposed strategy exhibits good linearity over a wide range of 10(-13)-10(-7) M with a low detection limit of 30 fM. And this method had been successfully applied in real water samples. Our strategy provided a versatile, low-cost and user-friendly paper-based monitoring platform for rapid and ultrasensitive analysis of heavy metal ions and thus had potential applications in food safety and public health.
资助机构	National Natural ScienceFoundat i o n of China ; Natural Science Foundation of Shandong Province
收录类别	SCI
语种	英语
关键词[WOS]	COLD VAPOR GENERATION ; ATOMIC-EMISSION-SPECTROMETRY ; CATHODE GLOW-DISCHARGE ; SPECIATION ANALYSIS ; RAPID DETECTION ; ICP-MS ; HG-II ; PHASE ; GOLD ; APTASENSOR
研究领域[WOS]	Chemistry ; Electrochemistry ; Instruments & Instrumentation
WOS记录号	WOS:000806675000005
引用统计	被引频次：19[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31208
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Chen, Yan; Li, Bowei; Chen, Lingxin
作者单位	1.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China 2.Shandong Agr & Engn Univ, Sch Resources & Environm Engn, Jinan 250100, Peoples R China 3.Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Fu, Xiuli,Lin, Hao,Qi, Ji,et al. A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection[J]. SENSORS AND ACTUATORS B-CHEMICAL,2022,362:7.
APA	Fu, Xiuli.,Lin, Hao.,Qi, Ji.,Li, Fengling.,Chen, Yan.,...&Chen, Lingxin.(2022).A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection.SENSORS AND ACTUATORS B-CHEMICAL,362,7.
MLA	Fu, Xiuli,et al."A tetrahedral DNA nanostructure functionalized paper-based platform for ultrasensitive colorimetric mercury detection".SENSORS AND ACTUATORS B-CHEMICAL 362(2022):7.