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Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application
Tan, Wenqiang1,2; Lin, Conghao3; Zhang, Jingjing1,2; Li, Qing1,2; Guo, Zhanyong1,2
Source PublicationMOLECULES
2022-05-01
Volume27Issue:9Pages:13
Keywordhydroxypropyltrimethyl ammonium chitosan derivatives alpha-lipoic acid antioxidant activity
DOI10.3390/molecules27092682
AbstractHydroxypropyltrimethyl ammonium chloride chitosan (HACC) is one of the most important water-soluble chitosan derivatives; its derivatives have gained growing attention due to their potential biomedical applications. Here, hydroxypropyltrimethyl ammonium chitosan derivatives bearing thioctate (HACTs), with different degrees of substitution of thioctate, were prepared using HACC and alpha-lipoic acid as the reaction precursors, using an ion exchange method. The structural characteristics of the synthesized derivatives were confirmed by FTIR, H-1 NMR, and C-13 NMR spectroscopy. In addition, their antioxidant behaviors were also investigated in vitro by the assays of reducing power, and scavenging activities against hydroxyl radicals and DPPH radicals. The antioxidant assay indicated that HACTs displayed strong antioxidant activity compared with HACC, especially in terms of reducing power. Besides, the antioxidant activities of the prepared products were further enhanced with the increase in the test concentration and the degrees of substitution of thioctate. At the maximum test concentration of 1.60 mg/mL, the absorbance value at 700 nm of HACTs, under the test conditions, was 4.346 +/- 0.296, while the absorbance value of HACC was 0.041 +/- 0.007. The aforementioned results support the use of HACTs as antioxidant biomaterials in food and the biomedical field.
Indexed BySCI
Language英语
WOS KeywordALPHA-LIPOIC ACID ; CARBOXYMETHYL CHITOSAN ; ENHANCED ANTIOXIDANT ; ANTIFUNGAL ; POLYSACCHARIDES ; DESIGN
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS IDWOS:000796152900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/31075
Collection海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
3.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China
Recommended Citation
GB/T 7714
Tan, Wenqiang,Lin, Conghao,Zhang, Jingjing,et al. Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application[J]. MOLECULES,2022,27(9):13.
APA Tan, Wenqiang,Lin, Conghao,Zhang, Jingjing,Li, Qing,&Guo, Zhanyong.(2022).Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application.MOLECULES,27(9),13.
MLA Tan, Wenqiang,et al."Synthesis of Hydroxypropyltrimethyl Ammonium Chitosan Derivatives Bearing Thioctate and the Potential for Antioxidant Application".MOLECULES 27.9(2022):13.
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