Effects of Inulin Propionate Ester on Obesity-Related Metabolic Syndrome and Intestinal Microbial Homeostasis in Diet-Induced Obese Mice
Zhu, Xiaozhen1,4; Zhang, Xia1,4; Yi, Yuetao1; Meng, Xianyao1,4; Jia, Chenchen1,4; Yi, Yuetao2; Zhang, Hanhan3; Gao, Xuelu4; Gao, Xuelu5; Hou, Yang6; Chao, Bo7; Fan, Wenyong7; Li, Xinrui7
Source PublicationACS OMEGA
ISSN2470-1343
2020-06-09
Volume5Issue:22Pages:12865-12876
KeywordCHAIN FATTY-ACIDS INTEGRATED BIOMARKER RESPONSE INSULIN SENSITIVITY GUT MICROBIOTA ENERGY-EXPENDITURE INFLAMMATION FRUCTANS BENEFITS HEALTH FIBER
DOI10.1021/acsomega.0c00649
AbstractShort-chain fatty acid (SCFA) plays an important role in improving obesity and related metabolic syndrome induced by high-fat diet. We used the prepared inulin propionate ester (IPE) as a system for the targeted release of propionate to the colon to elucidate the role of IPE in regulating obesity and metabolic syndrome, and intestinal microbial homeostasis, in diet-induced obese mice. With this strategy, IPE significantly increased the SCFA contents in the colon and resulted in significant body weight reduction, insulin resistance amelioration, and gastrointestinal hormone (glucagon-like peptide and peptide YY) secretion (P < 0.05). The IPE intervention reduced liver fatty accumulation, which improved obesity-related fatty liver disease (P < 0.05). IPE supplementation increased the richness and diversity of the microbial community and altered bacterial population at both the phylum and family level. Intestinal microbial results showed that the relative abundance of Desulfovibrionaceae and Erysipelotrichaceae, which promote the production of inflammatory factors, was reduced. Our results demonstrate that IPE can be used as an effective strategy for delivering propionate to obese mice colon, which can ameliorate obesity and associated metabolic syndrome and modify intestinal microbial homeostasis.
Funding OrganizationNational Key Research & Development Program in China [2019YFD1002704] ; Science and Technology Service Initiative of the Chinese Academy of Sciences [KFJ-STS-ZDTP-023] ; Key Research and Development Program of Yantai [2018XSCC046]
Indexed BySCI
Language英语
WOS KeywordCHAIN FATTY-ACIDS ; INTEGRATED BIOMARKER RESPONSE ; INSULIN SENSITIVITY ; GUT MICROBIOTA ; ENERGY-EXPENDITURE ; INFLAMMATION ; FRUCTANS ; BENEFITS ; HEALTH ; FIBER
WOS Research AreaChemistry
WOS IDWOS:000541503700029
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/30477
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;
2.Chinese Acad Sci, Ctr Ocean Megasci, Yantai 264003, Peoples R China;
3.Binzhou Med Univ, Key Lab Tumor Mol Biol, Dept Biochem & Mol Biol, Yantai 264003, Shandong, Peoples R China;
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
5.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China;
6.Beijing Dongcheng Dist Food & Drug Safety Monitor, Beijing 100050, Peoples R China;
7.Binzhou Med Univ, Sch Clin Med, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Xiaozhen,Zhang, Xia,Yi, Yuetao,et al. Effects of Inulin Propionate Ester on Obesity-Related Metabolic Syndrome and Intestinal Microbial Homeostasis in Diet-Induced Obese Mice[J]. ACS OMEGA,2020,5(22):12865-12876.
APA Zhu, Xiaozhen.,Zhang, Xia.,Yi, Yuetao.,Meng, Xianyao.,Jia, Chenchen.,...&Li, Xinrui.(2020).Effects of Inulin Propionate Ester on Obesity-Related Metabolic Syndrome and Intestinal Microbial Homeostasis in Diet-Induced Obese Mice.ACS OMEGA,5(22),12865-12876.
MLA Zhu, Xiaozhen,et al."Effects of Inulin Propionate Ester on Obesity-Related Metabolic Syndrome and Intestinal Microbial Homeostasis in Diet-Induced Obese Mice".ACS OMEGA 5.22(2020):12865-12876.
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