Synthesis, Characterization, and Evaluation of Nanoparticles Loading Adriamycin Based on 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan Grafting Folic Acid
Mi, Yingqi1,2,3; Zhang, Jingjing1,2; Zhang, Lulin4; Li, Qing1,2; Cheng, Yuanzheng4; Guo, Zhanyong1,2,3
Source PublicationPOLYMERS
2021-07-01
Volume13Issue:14Pages:17
Keywordchitosan nanoparticles drug release cytotoxicity
DOI10.3390/polym13142229
Corresponding AuthorCheng, Yuanzheng(chyzhu111@163.com) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
AbstractChitosan nanoparticles have been considered as potential candidates for drug loading/release in drug delivery systems. In this paper, nanoparticles (HACAFNP) loading adriamycin based on 2-hydroxypropyltrimethyl ammonium chloride chitosan grafting folic acid (HACF) were synthesized. The surface morphology of the novel nanoparticles was spherical or oval, and the nanoparticles exhibited a relatively small hydrodynamic diameter (85.6 +/- 2.04 nm) and positive zeta potential (+21.06 +/- 0.96 mV). The drug release of nanoparticles was assayed and represented a burst effect followed by a long-term steady release. Afterward, the antioxidant efficiencies of nanoparticles were assayed. In particular, the target nanoparticles exhibited significant enhancement in radical scavenging activities. Cytotoxicities against cancer cells (MCF-7, BGC-823, and HEPG-2) were estimated in vitro, and results showed nanoparticles inhibited the growth of cancer cells. It's worth noting that the inhibition index of HACAFNP against BGC-823 cells was 71.19% with the sample concentration of 25 mu g/mL, which was much higher than the inhibitory effect of ADM. It was demonstrated that the novel nanoparticles with dramatically enhanced biological activity, reduced cytotoxicity, and steady release could be used as the practical candidates for drug loading/release in a delivery system.
Funding OrganizationYouth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan
Indexed BySCI
Language英语
WOS KeywordDELIVERY
WOS Research AreaPolymer Science
WOS IDWOS:000677027000001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/29509
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
Corresponding AuthorCheng, Yuanzheng; Guo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Weifang Med Univ, Sch Pharm, Weifang 261053, Peoples R China
Recommended Citation
GB/T 7714
Mi, Yingqi,Zhang, Jingjing,Zhang, Lulin,et al. Synthesis, Characterization, and Evaluation of Nanoparticles Loading Adriamycin Based on 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan Grafting Folic Acid[J]. POLYMERS,2021,13(14):17.
APA Mi, Yingqi,Zhang, Jingjing,Zhang, Lulin,Li, Qing,Cheng, Yuanzheng,&Guo, Zhanyong.(2021).Synthesis, Characterization, and Evaluation of Nanoparticles Loading Adriamycin Based on 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan Grafting Folic Acid.POLYMERS,13(14),17.
MLA Mi, Yingqi,et al."Synthesis, Characterization, and Evaluation of Nanoparticles Loading Adriamycin Based on 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan Grafting Folic Acid".POLYMERS 13.14(2021):17.
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